Large ribosomal subunit protein uL23
Also known as: JW3280, b3318, rplW
Function
One of the early assembly proteins, it binds 23S rRNA; is essential for growth. One of the proteins that surround the polypeptide exit tunnel on the outside of the subunit. Acts as the docking site for trigger factor for Ffh binding to the ribosome (SRP54) and to nascent polypeptide chains.
Classification
- Family (Pfam)
- PF00276 Ribosomal_L23
- InterPro
- Nucleotide-bd_a/b_plait_sf, Ribosomal_uL23-like, Ribosomal_uL23/eL15/eS24_sf, Ribosomal_uL23_CS
- Functional cluster
- Small/Large Ribosomal Subunit Proteins
Experimental structures · PDB · 561
- 1ML5 EM 14.00A
- 2J28 EM 8.00A
- 2RDO EM 9.10A
- 2VRH EM 19.00A
- 3BBX EM 10.00A
- 3IY9 EM 14.10A
- 3J45 EM 9.50A
- 3J46 EM 10.10A
- 3J5L EM 6.60A
- 3J7Z EM 3.90A
- 3J8G EM 5.00A
- 3J9Y EM 3.90A
- … and 549 more
A predicted model is available from AlphaFold.
Gene Ontology · 6
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
- Large ribosomal subunit protein uL23 1.00
Co-cited proteins · studied together in the literature
- Large ribosomal subunit protein uL29 9 shared papers
- Signal recognition particle protein 2 shared papers
- Trigger factor 2 shared papers
- Large ribosomal subunit protein bL21 4 shared papers
- Protein translocase subunit SecE 2 shared papers
- Large ribosomal subunit protein uL24 4 shared papers
- Protein translocase subunit SecY 2 shared papers
- Large ribosomal subunit protein uL4 5 shared papers
- Large ribosomal subunit protein bL17 4 shared papers
- Large ribosomal subunit protein bL20 4 shared papers
- Large ribosomal subunit protein bL27 3 shared papers
- Large ribosomal subunit protein uL6 3 shared papers
Literature · 23 cited papers
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
- Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Nat. Struct. Mol. Biol. · 2011
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature · 2005
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- … and 11 more in the literature graph
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