Large ribosomal subunit protein uL6
Also known as: JW3267, b3305, rplF
Function
This protein binds directly to at least 2 domains of the 23S ribosomal RNA, thus is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Classification
- Family (Pfam)
- PF00347 Ribosomal_L6
- InterPro
- Ribosomal_uL6-like, Ribosomal_uL6-like_a/b-dom_sf, Ribosomal_uL6_a/b-dom, Ribosomal_uL6_bact, Ribosomal_uL6_CS
- Functional cluster
- Globins & Ribosomal Protein L6
Experimental structures · PDB · 516
- 1EG0 EM 11.50A
- 1ML5 EM 14.00A
- 2J28 EM 8.00A
- 2RDO EM 9.10A
- 3BBX EM 10.00A
- 3J5L EM 6.60A
- 3J7Z EM 3.90A
- 3J8G EM 5.00A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JBU EM 3.64A
- … and 504 more
A predicted model is available from AlphaFold.
Gene Ontology · 8
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
- Large ribosomal subunit protein uL6 1.00
Co-cited proteins · studied together in the literature
- Large ribosomal subunit protein uL6 1 shared papers
- Small ribosomal subunit protein uS5 1 shared papers
- Large ribosomal subunit protein bL21 3 shared papers
- Large ribosomal subunit protein uL14 4 shared papers
- Large ribosomal subunit protein bL27 3 shared papers
- Large ribosomal subunit protein uL30 3 shared papers
- Large ribosomal subunit protein bL25 3 shared papers
- Large ribosomal subunit protein uL11 3 shared papers
- Large ribosomal subunit protein bL9 3 shared papers
- Large ribosomal subunit protein uL29 3 shared papers
- Large ribosomal subunit protein uL15 3 shared papers
- Large ribosomal subunit protein uL2 3 shared papers
Literature · 21 cited papers
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
- Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol. Cell. Proteomics · 2009
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution. J. Mol. Biol. · 2000
- … and 9 more in the literature graph
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.