Large ribosomal subunit protein uL14

UniProt P0ADY3 Organism Escherichia coli (strain K12) Gene JW3272, b3310, rplN

Also known as: JW3272, b3310, rplN

Function

Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.

Classification

Family (Pfam): PF00238 Ribosomal_L14
InterPro: Ribosomal_uL14, Ribosomal_uL14_bact, Ribosomal_uL14_CS, Ribosomal_uL14_sf
Functional cluster: Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 549

1ML5 EM 14.00A
2J28 EM 8.00A
2RDO EM 9.10A
3BBX EM 10.00A
3IY9 EM 14.10A
3IZZ EM 10.80A
3J5L EM 6.60A
3J7Z EM 3.90A
3J8G EM 5.00A
3J9Y EM 3.90A
3J9Z EM 3.60A
3JA1 EM 3.60A
… and 537 more

A predicted model is available from AlphaFold.

Gene Ontology · 6

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein uS17 2 shared papers
Small ribosomal subunit protein uS12 2 shared papers
Large ribosomal subunit protein bL19 4 shared papers
Large ribosomal subunit protein uL6 4 shared papers
Ribosomal silencing factor RsfS 2 shared papers
Large ribosomal subunit protein bL32 3 shared papers
Large ribosomal subunit protein uL2 4 shared papers
Large ribosomal subunit protein uL30 3 shared papers
Large ribosomal subunit protein bL21 3 shared papers
Large ribosomal subunit protein uL14 1 shared papers
Protein Iojap, chloroplastic 1 shared papers
Ribosomal silencing factor RsfS 1 shared papers

Literature · 20 cited papers

Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol. Cell · 2021
Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS Genet. · 2012
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
… and 8 more in the literature graph

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