Small ribosomal subunit protein uS12

UniProt P0A7S3 Organism Escherichia coli (strain K12) Gene JW3304, b3342, rpsL, strA

Also known as: JW3304, b3342, rpsL, strA

Function

With S4 and S5 plays an important role in translational accuracy.

Classification

Family (Pfam): PF00164 Ribosom_S12_S23
InterPro: NA-bd_OB-fold, Ribosomal_uS12, Ribosomal_uS12_bact
Functional cluster: Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 524

1MJ1 EM 13.00A
1ZN1 EM 14.10A
2YKR EM 9.80A
3DEG EM
3EP2 EM
3EQ3 EM
3EQ4 EM
3IY8 EM 14.10A
3J0D EM 11.10A
3J0E EM 9.90A
3J9Y EM 3.90A
3J9Z EM 3.60A
… and 512 more

A predicted model is available from AlphaFold.

Gene Ontology · 15

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein uS7 4 shared papers
Small ribosomal subunit protein uS4 3 shared papers
Elongation factor G 1 shared papers
Small ribosomal subunit protein uS17 3 shared papers
Elongation factor Tu 2 1 shared papers
Large ribosomal subunit protein uL14 2 shared papers
Small ribosomal subunit protein bS18 2 shared papers
Small ribosomal subunit protein uS9 2 shared papers
Small ribosomal subunit protein uS3 2 shared papers
Small ribosomal subunit protein uS14 1 shared papers
Small ribosomal subunit protein uS2 2 shared papers
Small ribosomal subunit protein bS16 1 shared papers

Literature · 22 cited papers

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol. Cell. Proteomics · 2009
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex. Nat. Struct. Biol. · 2002
All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J. · 2002
… and 10 more in the literature graph

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