Small ribosomal subunit protein uS9
Also known as: JW3199, b3230, rpsI
Function
The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. Mutations that decrease this affinity are suppressed in the 70S ribosome.
Classification
- Family (Pfam)
- PF00380 Ribosomal_S9
- InterPro
- Ribosomal_Su5_D2-typ_SF, Ribosomal_uS9, Ribosomal_uS9_bact_plastid, Ribosomal_uS9_CS, Ribsml_uS5_D2-typ_fold_subgr
- Functional cluster
- Core Ribosomal Proteins (L2/L14/L16)
Experimental structures · PDB · 509
- 2YKR EM 9.80A
- 3IY8 EM 14.10A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JBU EM 3.64A
- 3JBV EM 3.32A
- 3JCD EM 3.70A
- 3JCE EM 3.20A
- 3JCJ EM 3.70A
- 3JCN EM 4.60A
- 4A2I EM 16.50A
- … and 497 more
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
- Small ribosomal subunit protein uS9 1.00
Co-cited proteins · studied together in the literature
- Large ribosomal subunit protein uL13 1 shared papers
- Small ribosomal subunit protein uS5 2 shared papers
- Small ribosomal subunit protein uS13 3 shared papers
- Small ribosomal subunit protein uS19 2 shared papers
- Large ribosomal subunit protein bL27 2 shared papers
- Small ribosomal subunit protein uS7 3 shared papers
- Large ribosomal subunit protein bL33 1 shared papers
- Large ribosomal subunit protein uL1 2 shared papers
- Small ribosomal subunit protein bS18 2 shared papers
- Large ribosomal subunit protein uL16 1 shared papers
- Small ribosomal subunit protein uS17 2 shared papers
- Small ribosomal subunit protein uS3 2 shared papers
Literature · 18 cited papers
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Creating ribosomes with an all-RNA 30S subunit P site. Proc. Natl. Acad. Sci. U.S.A. · 2004
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
- Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
- Escherichia coli proteome analysis using the gene-protein database. Electrophoresis · 1997
- … and 6 more in the literature graph
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