Small ribosomal subunit protein uS7

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, where it has been shown to contact mRNA. Has been shown to contact tRNA in both the P and E sites; it probably blocks exit of the E site tRNA.

Classification

Family (Pfam)

PF00177 Ribosomal_S7

InterPro

Ribosomal_uS7, Ribosomal_uS7_bact_org, Ribosomal_uS7_CS, Ribosomal_uS7_dom, Ribosomal_uS7_dom_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 535

• 1EG0 EM 11.50A
• 1ML5 EM 14.00A
• 2YKR EM 9.80A
• 3J5S EM 7.50A
• 3J9Y EM 3.90A
• 3J9Z EM 3.60A
• 3JA1 EM 3.60A
• 3JBU EM 3.64A
• 3JBV EM 3.32A
• 3JCD EM 3.70A
• 3JCE EM 3.20A
• 3JCJ EM 3.70A
• … and 523 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022627 cytosolic small ribosomal subunit
• GO:0016020 membrane
• GO:0005840 ribosome
• GO:0003729 mRNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0002181 cytoplasmic translation
• GO:0017148 negative regulation of translation
• GO:0000028 ribosomal small subunit assembly
• GO:0006412 translation

Drugs targeting this protein · 62

• TELITHROMYCIN inhibitor
• DEMECLOCYCLINE HYDROCHLORIDE inhibitor
• ERYTHROMYCIN LACTOBIONATE inhibitor
• ERYTHROMYCIN STEARATE inhibitor
• CLINDAMYCIN HYDROCHLORIDE inhibitor
• CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
• QUINUPRISTIN inhibitor
• ERYTHROMYCIN ETHYLSUCCINATE inhibitor
• DOXYCYCLINE inhibitor
• CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
• MINOCYCLINE HYDROCHLORIDE inhibitor
• DALFOPRISTIN inhibitor
• TETRACYCLINE PHOSPHATE COMPLEX inhibitor
• DIRITHROMYCIN inhibitor
• TEDIZOLID inhibitor
• LINEZOLID inhibitor
• CHLORAMPHENICOL inhibitor
• TETRACYCLINE inhibitor
• KANAMYCIN SULFATE inhibitor
• LINCOMYCIN inhibitor
• OXYTETRACYCLINE inhibitor
• OXYTETRACYCLINE HYDROCHLORIDE inhibitor
• DELPAZOLID inhibitor
• CLARITHROMYCIN inhibitor
• BEKANAMYCIN inhibitor
• ERAVACYCLINE inhibitor
• OMADACYCLINE TOSYLATE inhibitor
• TYLVALOSIN TARTRATE inhibitor
• TEDIZOLID PHOSPHATE inhibitor
• GAMITHROMYCIN inhibitor
• CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
• METHACYCLINE HYDROCHLORIDE inhibitor
• PAROMOMYCIN SULFATE inhibitor
• SISOMICIN inhibitor
• ERYTHROMYCIN ESTOLATE inhibitor
• ERAVACYCLINE DIHYDROCHLORIDE inhibitor
• JOSAMYCIN inhibitor
• PLAZOMICIN SULFATE inhibitor
• MECLOCYCLINE SULFOSALICYLATE inhibitor
• TILDIPIROSIN inhibitor
• QUINUPRISTIN/DALFOPRISTIN inhibitor
• CLINDAMYCIN PHOSPHATE inhibitor
• STREPTOMYCIN SULFATE inhibitor
• DIHYDROSTREPTOMYCIN SULFATE inhibitor
• CONTEZOLID inhibitor
• ERYTHROMYCIN GLUCEPTATE inhibitor
• LEFAMULIN ACETATE inhibitor
• CADAZOLID inhibitor
• TIGECYCLINE inhibitor
• OXYTETRACYCLINE CALCIUM inhibitor
• SPECTINOMYCIN HYDROCHLORIDE inhibitor
• DOXYCYCLINE HYCLATE inhibitor
• NETILMICIN SULFATE inhibitor
• PIRLIMYCIN HYDROCHLORIDE inhibitor
• CETHROMYCIN inhibitor
• CONTEZOLID ACEFOSAMIL inhibitor
• AMIKACIN SULFATE inhibitor
• NAFITHROMYCIN inhibitor
• TETRACYCLINE HYDROCHLORIDE inhibitor
• RADEZOLID inhibitor
• AZITHROMYCIN inhibitor
• ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 1.00
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90
• Small ribosomal subunit protein uS7 0.90

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS11 4 shared papers
• Small ribosomal subunit protein uS12 4 shared papers
• Elongation factor G 2 shared papers
• Elongation factor P 1 shared papers
• Small ribosomal subunit protein uS4 3 shared papers
• Elongation factor G 1 shared papers
• Small ribosomal subunit protein uS7 1 shared papers
• Small ribosomal subunit protein uS9 3 shared papers
• Small ribosomal subunit protein uS19 2 shared papers
• Large ribosomal subunit protein bL27 2 shared papers
• Small ribosomal subunit protein uS13 2 shared papers
• Large ribosomal subunit protein bL33 1 shared papers

Literature · 26 cited papers

• Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Mol. Cell · 2017
• Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
• Translational termination without a stop codon. Science · 2016
• Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
• Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
• Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
• Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
• All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
• Interaction of translation initiation factor 3 with the 30S ribosomal subunit. Mol. Cell · 2001
• Ribosomal protein S7 from Escherichia coli uses the same determinants to bind 16S ribosomal RNA and its messenger RNA. Nucleic Acids Res. · 2001
• … and 14 more in the literature graph