Large ribosomal subunit protein bL33

Classification

Family (Pfam)

PF00471 Ribosomal_L33

InterPro

Ribosomal_bL33, Ribosomal_bL33_CS, Ribosomal_bL33_sf, Ribosomal_zn-bd

Functional cluster

Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 508

• 2J28 EM 8.00A
• 2RDO EM 9.10A
• 3BBX EM 10.00A
• 3J5L EM 6.60A
• 3J5S EM 7.50A
• 3J7Z EM 3.90A
• 3J9Y EM 3.90A
• 3J9Z EM 3.60A
• 3JA1 EM 3.60A
• 3JBU EM 3.64A
• 3JBV EM 3.32A
• 3JCD EM 3.70A
• … and 496 more

A predicted model is available from AlphaFold.

Gene Ontology · 8

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0002181 cytoplasmic translation
• GO:0046677 response to antibiotic
• GO:0000027 ribosomal large subunit assembly

Drugs targeting this protein · 62

• TELITHROMYCIN inhibitor
• DEMECLOCYCLINE HYDROCHLORIDE inhibitor
• ERYTHROMYCIN LACTOBIONATE inhibitor
• ERYTHROMYCIN STEARATE inhibitor
• CLINDAMYCIN HYDROCHLORIDE inhibitor
• CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
• QUINUPRISTIN inhibitor
• ERYTHROMYCIN ETHYLSUCCINATE inhibitor
• DOXYCYCLINE inhibitor
• CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
• MINOCYCLINE HYDROCHLORIDE inhibitor
• DALFOPRISTIN inhibitor
• TETRACYCLINE PHOSPHATE COMPLEX inhibitor
• DIRITHROMYCIN inhibitor
• TEDIZOLID inhibitor
• LINEZOLID inhibitor
• CHLORAMPHENICOL inhibitor
• TETRACYCLINE inhibitor
• KANAMYCIN SULFATE inhibitor
• LINCOMYCIN inhibitor
• OXYTETRACYCLINE inhibitor
• OXYTETRACYCLINE HYDROCHLORIDE inhibitor
• DELPAZOLID inhibitor
• CLARITHROMYCIN inhibitor
• BEKANAMYCIN inhibitor
• ERAVACYCLINE inhibitor
• OMADACYCLINE TOSYLATE inhibitor
• TYLVALOSIN TARTRATE inhibitor
• TEDIZOLID PHOSPHATE inhibitor
• GAMITHROMYCIN inhibitor
• CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
• METHACYCLINE HYDROCHLORIDE inhibitor
• PAROMOMYCIN SULFATE inhibitor
• SISOMICIN inhibitor
• ERYTHROMYCIN ESTOLATE inhibitor
• ERAVACYCLINE DIHYDROCHLORIDE inhibitor
• JOSAMYCIN inhibitor
• PLAZOMICIN SULFATE inhibitor
• MECLOCYCLINE SULFOSALICYLATE inhibitor
• TILDIPIROSIN inhibitor
• QUINUPRISTIN/DALFOPRISTIN inhibitor
• CLINDAMYCIN PHOSPHATE inhibitor
• STREPTOMYCIN SULFATE inhibitor
• DIHYDROSTREPTOMYCIN SULFATE inhibitor
• CONTEZOLID inhibitor
• ERYTHROMYCIN GLUCEPTATE inhibitor
• LEFAMULIN ACETATE inhibitor
• CADAZOLID inhibitor
• TIGECYCLINE inhibitor
• OXYTETRACYCLINE CALCIUM inhibitor
• SPECTINOMYCIN HYDROCHLORIDE inhibitor
• DOXYCYCLINE HYCLATE inhibitor
• NETILMICIN SULFATE inhibitor
• PIRLIMYCIN HYDROCHLORIDE inhibitor
• CETHROMYCIN inhibitor
• CONTEZOLID ACEFOSAMIL inhibitor
• AMIKACIN SULFATE inhibitor
• NAFITHROMYCIN inhibitor
• TETRACYCLINE HYDROCHLORIDE inhibitor
• RADEZOLID inhibitor
• AZITHROMYCIN inhibitor
• ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00
• Large ribosomal subunit protein bL33 1.00

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein bL28 3 shared papers
• Large ribosomal subunit protein bL27 3 shared papers
• Large ribosomal subunit protein uL16 3 shared papers
• Large ribosomal subunit protein uL5 3 shared papers
• Large ribosomal subunit protein uL1 2 shared papers
• Small ribosomal subunit protein uS9 1 shared papers
• Small ribosomal subunit protein uS19 1 shared papers
• Small ribosomal subunit protein uS13 1 shared papers
• Large ribosomal subunit protein uL30 2 shared papers
• Small ribosomal subunit protein uS7 1 shared papers
• Large ribosomal subunit protein bL32 2 shared papers
• Large ribosomal subunit protein bL34 2 shared papers

Literature · 16 cited papers

• Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
• Translational termination without a stop codon. Science · 2016
• Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
• Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
• Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
• Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
• Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
• Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
• Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
• The complete genome sequence of Escherichia coli K-12. Science · 1997
• … and 4 more in the literature graph