Small ribosomal subunit protein uS19
Also known as: JW3278, b3316, rpsS
Function
In the E.coli 70S ribosome in the initiation state it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model with bound EF-G. The 23S rRNA contact site in bridge B1a is modeled to differ in different ribosomal states, contacting alternately S13 or S19. In the 3.5 angstroms resolved ribosome structures the contacts between L5, S13 and S19 bridge B1b are different, confirming the dynamic nature of this interaction. Bridge B1a is not visible in the crystallized ribosomes due to 23S rRNA disorder.
Classification
- Family (Pfam)
- PF00203 Ribosomal_S19
- InterPro
- Ribosomal_uS19, Ribosomal_uS19_bact, Ribosomal_uS19_CS, Ribosomal_uS19_SF
- Functional cluster
- Small-Subunit Ribosomal Proteins
Experimental structures · PDB · 510
- 2YKR EM 9.80A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JBU EM 3.64A
- 3JBV EM 3.32A
- 3JCD EM 3.70A
- 3JCE EM 3.20A
- 3JCJ EM 3.70A
- 3JCN EM 4.60A
- 4A2I EM 16.50A
- 4ADV EM 13.50A
- … and 498 more
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
- Small ribosomal subunit protein uS19 1.00
Co-cited proteins · studied together in the literature
- Small ribosomal subunit protein uS13 4 shared papers
- Ribosome maturation factor RimM 1 shared papers
- Large ribosomal subunit protein uL1 2 shared papers
- Elongation factor G 1 shared papers
- Large ribosomal subunit protein uL5 2 shared papers
- Large ribosomal subunit protein uL16 2 shared papers
- Small ribosomal subunit protein uS9 2 shared papers
- Small ribosomal subunit protein uS17 2 shared papers
- Small ribosomal subunit protein uS3 2 shared papers
- Large ribosomal subunit protein bL33 1 shared papers
- Small ribosomal subunit protein uS7 2 shared papers
- Small ribosomal subunit protein uS10 2 shared papers
Literature · 17 cited papers
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- The PRC-barrel domain of the ribosome maturation protein RimM mediates binding to ribosomal protein S19 in the 30S ribosomal subunits. RNA · 2004
- Locking and unlocking of ribosomal motions. Cell · 2003
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
- Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
- … and 5 more in the literature graph
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