Large ribosomal subunit protein uL11
Also known as: JW3946, b3983, relC, rplK
Function
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Classification
- Family (Pfam)
- PF00298 Ribosomal_L11, PF03946 Ribosomal_L11_N
- InterPro
- Ribosomal_uL11, Ribosomal_uL11_bact, Ribosomal_uL11_C, Ribosomal_uL11_C_sf, Ribosomal_uL11_CS, Ribosomal_uL11_N, Ribosomal_uL11_N_sf
- Functional cluster
- Ribosomal Protein L11
Experimental structures · PDB · 327
- 1EG0 EM 11.50A
- 1MJ1 EM 13.00A
- 1ML5 EM 14.00A
- 2J28 EM 8.00A
- 2RDO EM 9.10A
- 3DEG EM
- 3EP2 EM
- 3EQ3 EM
- 3EQ4 EM
- 3J0D EM 11.10A
- 3J5L EM 6.60A
- 3J7Z EM 3.90A
- … and 315 more
A predicted model is available from AlphaFold.
Gene Ontology · 11
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0022625 cytosolic large ribosomal subunit
- GO:0070180 large ribosomal subunit rRNA binding
- GO:0019843 rRNA binding
- GO:0003735 structural constituent of ribosome
- GO:0002181 cytoplasmic translation
- GO:0000027 ribosomal large subunit assembly
- GO:0015968 stringent response
- GO:0006412 translation
- GO:0006415 translational termination
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
- Large ribosomal subunit protein uL11 1.00
Co-cited proteins · studied together in the literature
- Transcription termination/antitermination protein NusG 1 shared papers
- Large ribosomal subunit protein uL1 4 shared papers
- Large ribosomal subunit protein uL10 3 shared papers
- Protein translocase subunit SecE 1 shared papers
- Large ribosomal subunit protein bL12 3 shared papers
- Large ribosomal subunit protein bL9 4 shared papers
- Large ribosomal subunit protein uL6 3 shared papers
- Large ribosomal subunit protein uL10 1 shared papers
- Large ribosomal subunit protein bL12 1 shared papers
- Large ribosomal subunit protein bL25 3 shared papers
- Large ribosomal subunit protein uL2 3 shared papers
- Large ribosomal subunit protein uL14 3 shared papers
Literature · 21 cited papers
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
- Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Identification of lysine succinylation as a new post-translational modification. Nat. Chem. Biol. · 2011
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Heptameric (L12)6/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria. Proc. Natl. Acad. Sci. U.S.A. · 2005
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- … and 9 more in the literature graph
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