Large ribosomal subunit protein uL3
Also known as: JW3282, b3320, rplC
Function
One of two assembly initiator proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Classification
- Family (Pfam)
- PF00297 Ribosomal_L3
- InterPro
- Ribosomal_uL3, Ribosomal_uL3_bact_org, Ribosomal_uL3_CS, Transl_B-barrel_sf
- Functional cluster
- Large Ribosomal Subunit Proteins
Experimental structures · PDB · 600
- 1ML5 EM 14.00A
- 2J28 EM 8.00A
- 2RDO EM 9.10A
- 3BBX EM 10.00A
- 3IY9 EM 14.10A
- 3J5L EM 6.60A
- 3J7Z EM 3.90A
- 3J8G EM 5.00A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JBU EM 3.64A
- … and 588 more
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
- Large ribosomal subunit protein uL3 1.00
Co-cited proteins · studied together in the literature
- Large ribosomal subunit protein uL24 4 shared papers
- Putative general secretion pathway protein B 1 shared papers
- Small ribosomal subunit protein uS10 2 shared papers
- Large ribosomal subunit protein uL2 5 shared papers
- Ribosomal protein uL3 glutamine methyltransferase 1 shared papers
- Release factor glutamine methyltransferase 1 shared papers
- Cell division activator CedA 1 shared papers
- Large ribosomal subunit protein bL9 4 shared papers
- Large ribosomal subunit protein uL16 4 shared papers
- Putative RNA-binding protein YbcJ 1 shared papers
- Isocitrate dehydrogenase [NADP] 1 shared papers
- Peptide chain release factor RF1 1 shared papers
Literature · 23 cited papers
- Identification of functional interactome of a key cell division regulatory protein CedA of E.coli. Int. J. Biol. Macromol. · 2018
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
- Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Identification of lysine succinylation as a new post-translational modification. Nat. Chem. Biol. · 2011
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- … and 11 more in the literature graph
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