Large ribosomal subunit protein uL18
Also known as: JW3266, b3304, rplR
Function
This is one of the proteins that mediates the attachment of the 5S rRNA subcomplex onto the large ribosomal subunit where it forms part of the central protuberance. Binds stably to 5S rRNA; increases binding abilities of L5 in a cooperative fashion; both proteins together confer 23S rRNA binding. The 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Classification
- Family (Pfam)
- PF00861 Ribosomal_L18p
- InterPro
- Ribosomal_L18, Ribosomal_uL18_bac/plant/anim, Ribosomal_uL18_bact
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 528
- 1ML5 EM 14.00A
- 2J28 EM 8.00A
- 2RDO EM 9.10A
- 3BBX EM 10.00A
- 3J5L EM 6.60A
- 3J7Z EM 3.90A
- 3J8G EM 5.00A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JBU EM 3.64A
- 3JBV EM 3.32A
- … and 516 more
A predicted model is available from AlphaFold.
Gene Ontology · 6
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
- Large ribosomal subunit protein uL18 1.00
Co-cited proteins · studied together in the literature
- Large ribosomal subunit protein uL5 6 shared papers
- Large ribosomal subunit protein uL18 1 shared papers
- Large ribosomal subunit protein bL25 4 shared papers
- Large ribosomal subunit protein uL30 3 shared papers
- Large ribosomal subunit protein uL15 3 shared papers
- Small ribosomal subunit protein uS14 1 shared papers
- Large ribosomal subunit protein uL6 3 shared papers
- Large ribosomal subunit protein uL24 3 shared papers
- Small ribosomal subunit protein uS8 1 shared papers
- Large ribosomal subunit protein uL14 3 shared papers
- Small ribosomal subunit protein uS5 1 shared papers
- Large ribosomal subunit protein bL33 2 shared papers
Literature · 21 cited papers
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
- Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- Phosphorylation of ribosomal protein L18 is required for its folding and binding to 5S rRNA. Biochemistry · 1999
- Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
- … and 9 more in the literature graph
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