Large ribosomal subunit protein bL36A
Also known as: JW3261, b3299, rpmJ1
Function
One of the last ribosomal proteins to be assembled in the 50S subunit, it contacts a number of helices in the 23S rRNA, acting as molecular glue. The simultaneous presence of uL16 and bL36 probably triggers ObgE's GTPase activity and eventual dissociation from the mature 50S ribosomal subunit.
Classification
- Family (Pfam)
- PF00444 Ribosomal_L36
- InterPro
- Ribosomal_bL36, Ribosomal_bL36_sp
- Functional cluster
- Bacterial Ribosomal Proteins
Experimental structures · PDB · 498
- 2J28 EM 8.00A
- 2RDO EM 9.10A
- 3BBX EM 10.00A
- 3J5L EM 6.60A
- 3J7Z EM 3.90A
- 3J8G EM 5.00A
- 3J9Y EM 3.90A
- 3J9Z EM 3.60A
- 3JA1 EM 3.60A
- 3JBU EM 3.64A
- 3JBV EM 3.32A
- 3JCD EM 3.70A
- … and 486 more
A predicted model is available from AlphaFold.
Gene Ontology · 6
Drugs targeting this protein · 62
- TELITHROMYCIN inhibitor
- DEMECLOCYCLINE HYDROCHLORIDE inhibitor
- ERYTHROMYCIN LACTOBIONATE inhibitor
- ERYTHROMYCIN STEARATE inhibitor
- CLINDAMYCIN HYDROCHLORIDE inhibitor
- CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
- QUINUPRISTIN inhibitor
- ERYTHROMYCIN ETHYLSUCCINATE inhibitor
- DOXYCYCLINE inhibitor
- CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
- MINOCYCLINE HYDROCHLORIDE inhibitor
- DALFOPRISTIN inhibitor
- TETRACYCLINE PHOSPHATE COMPLEX inhibitor
- DIRITHROMYCIN inhibitor
- TEDIZOLID inhibitor
- LINEZOLID inhibitor
- CHLORAMPHENICOL inhibitor
- TETRACYCLINE inhibitor
- KANAMYCIN SULFATE inhibitor
- LINCOMYCIN inhibitor
- OXYTETRACYCLINE inhibitor
- OXYTETRACYCLINE HYDROCHLORIDE inhibitor
- DELPAZOLID inhibitor
- CLARITHROMYCIN inhibitor
- BEKANAMYCIN inhibitor
- ERAVACYCLINE inhibitor
- OMADACYCLINE TOSYLATE inhibitor
- TYLVALOSIN TARTRATE inhibitor
- TEDIZOLID PHOSPHATE inhibitor
- GAMITHROMYCIN inhibitor
- CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
- METHACYCLINE HYDROCHLORIDE inhibitor
- PAROMOMYCIN SULFATE inhibitor
- SISOMICIN inhibitor
- ERYTHROMYCIN ESTOLATE inhibitor
- ERAVACYCLINE DIHYDROCHLORIDE inhibitor
- JOSAMYCIN inhibitor
- PLAZOMICIN SULFATE inhibitor
- MECLOCYCLINE SULFOSALICYLATE inhibitor
- TILDIPIROSIN inhibitor
- QUINUPRISTIN/DALFOPRISTIN inhibitor
- CLINDAMYCIN PHOSPHATE inhibitor
- STREPTOMYCIN SULFATE inhibitor
- DIHYDROSTREPTOMYCIN SULFATE inhibitor
- CONTEZOLID inhibitor
- ERYTHROMYCIN GLUCEPTATE inhibitor
- LEFAMULIN ACETATE inhibitor
- CADAZOLID inhibitor
- TIGECYCLINE inhibitor
- OXYTETRACYCLINE CALCIUM inhibitor
- SPECTINOMYCIN HYDROCHLORIDE inhibitor
- DOXYCYCLINE HYCLATE inhibitor
- NETILMICIN SULFATE inhibitor
- PIRLIMYCIN HYDROCHLORIDE inhibitor
- CETHROMYCIN inhibitor
- CONTEZOLID ACEFOSAMIL inhibitor
- AMIKACIN SULFATE inhibitor
- NAFITHROMYCIN inhibitor
- TETRACYCLINE HYDROCHLORIDE inhibitor
- RADEZOLID inhibitor
- AZITHROMYCIN inhibitor
- ERYTHROMYCIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36 1.00
- Large ribosomal subunit protein bL36 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
- Large ribosomal subunit protein bL36A 1.00
Co-cited proteins · studied together in the literature
- Large ribosomal subunit protein bL35 3 shared papers
- Large ribosomal subunit protein uL16 4 shared papers
- Small ribosomal subunit protein uS13 1 shared papers
- Ribosomal large subunit pseudouridine synthase D 1 shared papers
- Large ribosomal subunit protein bL19 3 shared papers
- RNA-binding protein YhbY 1 shared papers
- Large ribosomal subunit protein uL14 3 shared papers
- Dual-action ribosomal maturation protein DarP 1 shared papers
- Ribosomal silencing factor RsfS 1 shared papers
- GTPase ObgE/CgtA 2 shared papers
- Large ribosomal subunit protein uL30 2 shared papers
- Large ribosomal subunit protein bL33 2 shared papers
Literature · 15 cited papers
- Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol. Cell · 2021
- Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
- Translational termination without a stop codon. Science · 2016
- Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
- Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
- Molecular basis for the ribosome functioning as an L-tryptophan sensor. Cell Rep. · 2014
- Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol. · 2014
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
- Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
- Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
- … and 3 more in the literature graph
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