Large ribosomal subunit protein uL16

UniProt P27635 Organism Homo sapiens Gene DXS648E, QM, RPL10

Also known as: DXS648E, QM, RPL10

Function

Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.

Classification

Family (Pfam): PF00252 Ribosomal_L16
InterPro: Ribosomal_uL16, Ribosomal_uL16_CS_euk_arc, Ribosomal_uL16_dom, Ribosomal_uL16_euk_arch, Ribosomal_uL16_sf
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 31

2PA2 X-ray 2.50A
5AJ0 EM 3.50A
6OLE EM 3.10A
6OLF EM 3.90A
6OLG EM 3.40A
6OLI EM 3.50A
6OLZ EM 3.90A
6OM0 EM 3.10A
6OM7 EM 3.70A
6W6L EM 3.84A
7F5S EM 2.72A
8A3D EM 1.67A
… and 19 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Disease associations

autism, susceptibility to, X-linked 5 MONDO:0010449
intellectual disability, X-linked, syndromic, 35 MONDO:0030908

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Large ribosomal subunit protein uL16 1 shared papers
P3 protein 1 shared papers
Protein FAM50A 1 shared papers
Protein FAM3A 1 shared papers
Deoxyribonuclease-1-like 1 1 shared papers
Large ribosomal subunit protein eL29 1 shared papers
Large ribosomal subunit protein uL22 2 shared papers
Large ribosomal subunit protein uL2 2 shared papers
Large ribosomal subunit protein eL28 1 shared papers
Large ribosomal subunit protein eL34 2 shared papers
Large ribosomal subunit protein eL38 1 shared papers
Large ribosomal subunit protein uL6 1 shared papers

Literature · 23 cited papers

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
A novel mutation in RPL10 (Ribosomal Protein L10) causes X-Linked intellectual disability, cerebellar hypoplasia, and spondylo-epiphyseal dysplasia. Hum. Mutat. · 2015
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
RPL10 mutation segregating in a family with X-linked syndromic Intellectual Disability. Am. J. Med. Genet. A · 2015
A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans. Genetics · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. Am. J. Med. Genet. A · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. J. Mol. Biol. · 2008
Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. Mol. Psychiatry · 2006
Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer. Cancer Biol. Ther. · 2006
… and 11 more in the literature graph

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