Large ribosomal subunit protein eL28

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01778 Ribosomal_L28e

InterPro

Ribosomal_eL28, Ribosomal_eL28/Mak16

Functional cluster

Ribosomal S8 & Metabolic Enzymes

Experimental structures · PDB · 153

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 141 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0044297 cell body
• GO:0005737 cytoplasm
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0030425 dendrite
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL28 1.00
• Large ribosomal subunit protein eL28 1.00
• Large ribosomal subunit protein eL28 1.00
• Large ribosomal subunit protein eL28 1.00
• Large ribosomal subunit protein eL28y 0.77
• Large ribosomal subunit protein eL28z 0.75
• Large ribosomal subunit protein eL18 0.66
• Large ribosomal subunit protein eL18 0.66
• Large ribosomal subunit protein eL18 0.66
• Large ribosomal subunit protein eL18 0.65
• Large ribosomal subunit protein eL18 0.65
• Large ribosomal subunit protein eL18 0.65

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS7 1 shared papers
• Large ribosomal subunit protein uL15 1 shared papers
• Large ribosomal subunit protein eL21 2 shared papers
• Small ribosomal subunit protein uS4 1 shared papers
• Large ribosomal subunit protein uL18 2 shared papers
• Large ribosomal subunit protein eL29 1 shared papers
• Small ribosomal subunit protein uS14 1 shared papers
• Small ribosomal subunit protein eS10 1 shared papers
• Large ribosomal subunit protein eL14 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein uL1 1 shared papers
• Large ribosomal subunit protein uL30 1 shared papers

Literature · 14 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and biology of human chromosome 19. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 2 more in the literature graph