Small ribosomal subunit protein eS10

Function

Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF03501 S10_plectin

InterPro

Plectin_eS10_N, Ribosomal_eS10, WH-like_DNA-bd_sf

Functional cluster

Bacterial DNA-Binding & Transcription Regulators

Experimental structures · PDB · 163

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6FEC EM 6.30A
• 6G51 EM 4.10A
• 6G53 EM 4.50A
• … and 151 more

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005840 ribosome
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 9 MONDO:0013216

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS10 1.00
• Small ribosomal subunit protein eS10 0.98
• Small ribosomal subunit protein eS10 0.98
• Small ribosomal subunit protein eS10 0.98
• Small ribosomal subunit protein eS10 0.96
• Small ribosomal subunit protein eS10 0.90
• Small ribosomal subunit protein eS10 0.88
• Small ribosomal subunit protein eS10B 0.88
• Small ribosomal subunit protein eS10A 0.84
• Putative ribosomal protein eS10-like 0.83
• Small ribosomal subunit protein eS10A 0.82
• Small ribosomal subunit protein eS10B 0.81

Co-cited proteins · studied together in the literature

• OTU domain-containing protein 1 1 shared papers
• Small ribosomal subunit protein uS10 7 shared papers
• Small ribosomal subunit protein eS26 2 shared papers
• E3 ubiquitin-protein ligase ZNF598 4 shared papers
• Small ribosomal subunit protein uS3 5 shared papers
• Small ribosomal subunit protein uS5 4 shared papers
• Small ribosomal subunit protein uS7 3 shared papers
• Large ribosomal subunit protein eL28 1 shared papers
• Protein arginine N-methyltransferase 5 1 shared papers
• OTU domain-containing protein 3 1 shared papers
• Small ribosomal subunit protein uS4 3 shared papers
• Large ribosomal subunit protein uL15 2 shared papers

Literature · 17 cited papers

• Deubiquitinase OTUD1 resolves stalled translation on polyA and rare codon rich mRNAs. Mol. Cell. Biol. · 2022
• A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. Nat. Commun. · 2022
• Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized. Elife · 2020
• The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation. Mol. Cell · 2020
• The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nat. Commun. · 2017
• ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation. Mol. Cell · 2017
• Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination. Mol. Cell · 2016
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. J. Biol. Chem. · 2010
• Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Am. J. Hum. Genet. · 2010
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 5 more in the literature graph