Small ribosomal subunit protein eS26

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01283 Ribosomal_S26e

InterPro

Ribosomal_eS26, Ribosomal_eS26_CS, Ribosomal_eS26_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 153

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6G5H EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• … and 141 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
• GO:0005829 cytosol
• GO:0022627 cytosolic small ribosomal subunit
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0045202 synapse
• GO:0045296 cadherin binding
• GO:0003729 mRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0033119 negative regulation of RNA splicing
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 10 MONDO:0013217

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS26 1.00
• Small ribosomal subunit protein eS26 1.00
• Small ribosomal subunit protein eS26 1.00
• Small ribosomal subunit protein eS26 1.00
• Small ribosomal subunit protein eS26 1.00
• Small ribosomal subunit protein eS26 0.99
• Small ribosomal subunit protein eS26 0.95
• Putative ribosomal protein eS26-like 0.89
• Large ribosomal subunit protein eL21 0.80
• Small ribosomal subunit protein uS7c 0.79
• Small ribosomal subunit protein uS7c 0.79
• Small ribosomal subunit protein eS17 0.79

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein eS26 1 shared papers
• Pre-rRNA-processing protein TSR2 homolog 1 shared papers
• Small ribosomal subunit protein eS10 2 shared papers
• Small ribosomal subunit protein eS28 4 shared papers
• Small ribosomal subunit protein eS21 3 shared papers
• Large ribosomal subunit protein eL36 2 shared papers
• Small ribosomal subunit protein uS12 3 shared papers
• Large ribosomal subunit protein eL18 2 shared papers
• Small ribosomal subunit protein uS14 3 shared papers
• Large ribosomal subunit protein eL6 2 shared papers
• Large ribosomal subunit protein eL34 2 shared papers
• Large ribosomal subunit protein eL27 2 shared papers

Literature · 16 cited papers

• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• Diamond-Blackfan anemia with mandibulofacial dystostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28. Am. J. Med. Genet. A · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Am. J. Hum. Genet. · 2010
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 4 more in the literature graph