Small ribosomal subunit protein eS21

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01249 Ribosomal_S21e

InterPro

Ribosomal_eS21, Ribosomal_eS21_CS, Ribosomal_eS21_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 172

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6G18 EM 3.60A
• 6G4S EM 4.00A
• 6G51 EM 4.10A
• … and 160 more

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0005654 nucleoplasm
• GO:0005791 rough endoplasmic reticulum
• GO:0015935 small ribosomal subunit
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS21 1.00
• Small ribosomal subunit protein eS21 0.99
• Small ribosomal subunit protein eS21 0.97
• Small ribosomal subunit protein eS21 0.97
• Small ribosomal subunit protein eS21 0.97
• Small ribosomal subunit protein eS21 0.96
• Small ribosomal subunit protein eS21 0.95
• Small ribosomal subunit protein eS21 0.95
• Small ribosomal subunit protein uS7c 0.80
• Small ribosomal subunit protein uS7c 0.80
• Small ribosomal subunit protein uS7c 0.80
• Small ribosomal subunit protein uS7cz/uS7cy 0.79

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein eS28 5 shared papers
• Large ribosomal subunit protein eL36 3 shared papers
• Small ribosomal subunit protein uS14 5 shared papers
• Large ribosomal subunit protein eL34 4 shared papers
• Small ribosomal subunit protein uS12 4 shared papers
• Large ribosomal subunit protein eL18 3 shared papers
• Large ribosomal subunit protein eL21 4 shared papers
• Small ribosomal subunit protein eS26 3 shared papers
• Large ribosomal subunit protein eL27 3 shared papers
• Large ribosomal subunit protein eL6 2 shared papers
• Large ribosomal subunit protein uL11 1 shared papers
• Small ribosomal subunit protein uS7 3 shared papers

Literature · 18 cited papers

• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• … and 6 more in the literature graph