Small ribosomal subunit protein uS12

UniProt P62266 Organism Homo sapiens Gene RPS23

Also known as: RPS23

Function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF00164 Ribosom_S12_S23
InterPro: NA-bd_OB-fold, Ribosomal_uS12, Ribosomal_uS12_euk_arc
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 171

4CXG EM 8.70A
4CXH EM 8.90A
4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
… and 159 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

Disease associations

brachycephaly, trichomegaly, and developmental delay MONDO:0044311

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Prolyl 3-hydroxylase OGFOD1 2 shared papers
Small ribosomal subunit protein uS12B 1 shared papers
Small ribosomal subunit protein uS12A 1 shared papers
Small ribosomal subunit protein eS21 4 shared papers
Small ribosomal subunit protein eS28 4 shared papers
Small ribosomal subunit protein uS14 4 shared papers
Large ribosomal subunit protein eL36 2 shared papers
Large ribosomal subunit protein eL34 3 shared papers
Small ribosomal subunit protein uS12B 1 shared papers
Prolyl 3,4-dihydroxylase OGFOD1 1 shared papers
Prolyl 3,4-dihydroxylase ofd1 1 shared papers
Small ribosomal subunit protein eS26 3 shared papers

Literature · 16 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
A ribosomopathy reveals decoding defective ribosomes driving human dysmorphism. Am. J. Hum. Genet. · 2017
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
Structural snapshots of actively translating human ribosomes. Cell · 2015
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Structure of the human 80S ribosome. Nature · 2015
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proc. Natl. Acad. Sci. U.S.A. · 2014
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proc. Natl. Acad. Sci. U.S.A. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
… and 4 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.