Small ribosomal subunit protein uS14

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00253 Ribosomal_S14

InterPro

Ribosomal_uS14, Ribosomal_uS14_CS, RIbosomal_uS14_euk_arc, Ribosomal_uS14_sf

Functional cluster

Bacterial Ribosomal Proteins

Experimental structures · PDB · 163

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6FEC EM 6.30A
• 6G51 EM 4.10A
• 6G53 EM 4.50A
• … and 151 more

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005737 cytoplasm
• GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
• GO:0005829 cytosol
• GO:0022627 cytosolic small ribosomal subunit
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0005654 nucleoplasm
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0003735 structural constituent of ribosome
• GO:0008270 zinc ion binding
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 13 MONDO:0014394

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 1.00
• Small ribosomal subunit protein uS14 0.98
• Small ribosomal subunit protein uS14A 0.92
• Small ribosomal subunit protein uS14 0.92
• Small ribosomal subunit protein uS14 0.91
• Small ribosomal subunit protein uS14 0.91
• Small ribosomal subunit protein uS14z/uS14y/uS14x 0.90

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS14 1 shared papers
• Large ribosomal subunit protein eL21 5 shared papers
• Small ribosomal subunit protein eS21 5 shared papers
• Small ribosomal subunit protein uS7 4 shared papers
• Small ribosomal subunit protein eS28 5 shared papers
• Small ribosomal subunit protein uS4 4 shared papers
• Large ribosomal subunit protein eL36 3 shared papers
• Large ribosomal subunit protein eL34 4 shared papers
• Small ribosomal subunit protein uS12 4 shared papers
• Large ribosomal subunit protein eL28 1 shared papers
• Large ribosomal subunit protein eL18 3 shared papers
• Large ribosomal subunit protein uL15 2 shared papers

Literature · 17 cited papers

• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families. Blood · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol. Cell. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and analysis of human chromosome 14. Nature · 2003
• … and 5 more in the literature graph