Small ribosomal subunit protein uS4

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam)

PF00163 Ribosomal_S4, PF01479 S4

InterPro

Ribosomal_uS4, Ribosomal_uS4_CS, Ribosomal_uS4_euk_arc, Ribosomal_uS4_N, S4_RNA-bd, S4_RNA-bd_sf

Functional cluster

Archaeal Ribosomal & Replication Proteins

Experimental structures · PDB · 176

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6FEC EM 6.30A
• 6G18 EM 3.60A
• 6G4S EM 4.00A
• … and 164 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:1990904 ribonucleoprotein complex
• GO:0005840 ribosome
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0042274 ribosomal small subunit biogenesis

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS4 1.00
• Small ribosomal subunit protein uS4 1.00
• Small ribosomal subunit protein uS4 1.00
• Small ribosomal subunit protein uS4 1.00
• Small ribosomal subunit protein uS4 1.00
• Small ribosomal subunit protein uS4 0.98
• Small ribosomal subunit protein uS4 0.98
• Small ribosomal subunit protein uS4 0.96
• Small ribosomal subunit protein uS4 0.96
• Small ribosomal subunit protein uS4 0.95
• Small ribosomal subunit protein uS4y 0.94
• Small ribosomal subunit protein uS4A 0.91

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS7 4 shared papers
• Large ribosomal subunit protein eL28 1 shared papers
• Small ribosomal subunit protein uS14 4 shared papers
• Large ribosomal subunit protein uL15 2 shared papers
• Large ribosomal subunit protein eL21 3 shared papers
• Small ribosomal subunit protein eS10 3 shared papers
• Small ribosomal subunit protein eS12 3 shared papers
• Small ribosomal subunit protein eS25 2 shared papers
• Small ribosomal subunit protein uS9 2 shared papers
• Large ribosomal subunit protein uL18 1 shared papers
• Small ribosomal subunit protein eS21 3 shared papers
• Small ribosomal subunit protein eS27 3 shared papers

Literature · 19 cited papers

• Nucleolar maturation of the human small subunit processome. Science · 2021
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• Molecular composition of IMP1 ribonucleoprotein granules. Mol. Cell. Proteomics · 2007
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• … and 7 more in the literature graph