Small ribosomal subunit protein eS27

UniProt P42677 Organism Homo sapiens Gene MPS1, RPS27

Also known as: MPS1, RPS27

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for proper rRNA processing and maturation of 18S rRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF01667 Ribosomal_S27e
InterPro: Ribosomal_eS27, Ribosomal_eS27_Zn-bd_dom_sf, Ribosomal_zn-bd
Functional cluster: Photosystem Cytochrome b559 & Membrane Proteins

Experimental structures · PDB · 177

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 165 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

Disease associations

Diamond-Blackfan anemia 17 MONDO:0044310

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Large ribosomal subunit protein eL39 2 shared papers
Large ribosomal subunit protein eL27 2 shared papers
Small ribosomal subunit protein uS7 3 shared papers
Small ribosomal subunit protein eS12 3 shared papers
Small ribosomal subunit protein eS25 2 shared papers
Small ribosomal subunit protein uS9 2 shared papers
Small ribosomal subunit protein eS21 3 shared papers
Small ribosomal subunit protein uS4 3 shared papers
Small ribosomal subunit protein eS28 3 shared papers
Large ribosomal subunit protein eL24 2 shared papers
Large ribosomal subunit protein uL22 2 shared papers
Large ribosomal subunit protein eL37 2 shared papers

Literature · 20 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. Br. J. Haematol. · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell · 2006
The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
… and 8 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.