Large ribosomal subunit protein eL27

Function

Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs.

Classification

Family (Pfam)

PF00467 KOW, PF01777 Ribosomal_L27e

InterPro

KOW, Ribosomal_eL27, Ribosomal_eL27_CS, Ribosomal_eL27_KOW, Ribosomal_eL27_sf, Translation_prot_SH3-like_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 142

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 130 more

A predicted model is available from AlphaFold.

Gene Ontology · 22

• GO:0005737 cytoplasm
• GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:1990904 ribonucleoprotein complex
• GO:0005840 ribosome
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0006364 rRNA processing
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 16 MONDO:0044309

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 1.00
• Large ribosomal subunit protein eL27 0.99
• Large ribosomal subunit protein eL27 0.99
• Large ribosomal subunit protein eL27 0.98
• Large ribosomal subunit protein eL27 0.90

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein eS27 2 shared papers
• Large ribosomal subunit protein eL36 4 shared papers
• Large ribosomal subunit protein eL18 4 shared papers
• Large ribosomal subunit protein eL34 4 shared papers
• Large ribosomal subunit protein eL6 3 shared papers
• Small ribosomal subunit protein eS21 3 shared papers
• Large ribosomal subunit protein eL21 4 shared papers
• Small ribosomal subunit protein eS28 3 shared papers
• Small ribosomal subunit protein uS14 3 shared papers
• Small ribosomal subunit protein uS12 2 shared papers
• Small ribosomal subunit protein eS26 2 shared papers
• Large ribosomal subunit protein uL30 2 shared papers

Literature · 18 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• The DHX33 RNA Helicase Promotes mRNA Translation Initiation. Mol. Cell. Biol. · 2015
• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. Br. J. Haematol. · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits. Mol. Biol. Cell · 2010
• … and 6 more in the literature graph