Large ribosomal subunit protein uL30

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.

Classification

Family (Pfam)

PF00327 Ribosomal_L30, PF08079 Ribosomal_L30_N

InterPro

Ribo_uL30_ferredoxin-like_sf, Ribosomal_uL30, Ribosomal_uL30_CS, Ribosomal_uL30_euk, Ribosomal_uL30_euk_arc, Ribosomal_uL30_ferredoxin-like, Ribosomal_uL30_N_euk

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 155

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 143 more

A predicted model is available from AlphaFold.

Gene Ontology · 23

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005634 nucleus
• GO:0014069 postsynaptic density
• GO:1990904 ribonucleoprotein complex
• GO:0003677 DNA binding
• GO:0042802 identical protein binding
• GO:0003729 mRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:1901740 negative regulation of myoblast fusion
• GO:0042273 ribosomal large subunit biogenesis
• GO:0006364 rRNA processing
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL30 1.00
• Large ribosomal subunit protein uL30 1.00
• Large ribosomal subunit protein uL30 0.99
• Large ribosomal subunit protein uL30 0.98
• Large ribosomal subunit protein uL30 0.96
• Large ribosomal subunit protein uL30 0.95
• Large ribosomal subunit protein uL30 0.95
• Large ribosomal subunit protein uL30y 0.89
• Large ribosomal subunit protein uL30x 0.89
• Large ribosomal subunit protein uL30 0.89
• Large ribosomal subunit protein uL30w 0.88
• Large ribosomal subunit protein uL30 0.88

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL30 2 shared papers
• Large ribosomal subunit protein eL27 1 shared papers
• Large ribosomal subunit protein eL29 1 shared papers
• Eukaryotic translation initiation factor 3 subunit G 1 shared papers
• Large ribosomal subunit protein uL24 1 shared papers
• Eukaryotic translation initiation factor 3 subunit H 1 shared papers
• Large ribosomal subunit protein uL3 1 shared papers
• Large ribosomal subunit protein eL27 2 shared papers
• Large ribosomal subunit protein uL3 2 shared papers
• ATP-dependent RNA helicase DHX33 1 shared papers
• Large ribosomal subunit protein eL28 1 shared papers
• ATP-dependent RNA helicase DHX33 1 shared papers

Literature · 19 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• The DHX33 RNA Helicase Promotes mRNA Translation Initiation. Mol. Cell. Biol. · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat. Biotechnol. · 2005
• … and 7 more in the literature graph