Large ribosomal subunit protein uL3

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00297 Ribosomal_L3

InterPro

L3_arc_euk, Ribosomal_L3_dom_3_arc_sf, Ribosomal_uL3, Ribosomal_uL3_CS, Transl_B-barrel_sf

Functional cluster

DNA-Directed RNA Polymerase Subunits

Experimental structures · PDB · 154

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 142 more

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0005730 nucleolus
• GO:0005634 nucleus
• GO:0032991 protein-containing complex
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0007283 spermatogenesis
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL3 1.00
• Large ribosomal subunit protein uL3 1.00
• Large ribosomal subunit protein uL3 1.00
• Large ribosomal subunit protein uL3 1.00
• Large ribosomal subunit protein uL3 1.00
• Large ribosomal subunit protein uL3 1.00
• Large ribosomal subunit protein uL3 0.97
• Large ribosomal subunit protein uL3y 0.96
• Large ribosomal subunit protein uL3 0.96
• Large ribosomal subunit protein uL3z 0.96
• Large ribosomal subunit protein uL3 0.95
• Large ribosomal subunit protein uL3-like 0.95

Co-cited proteins · studied together in the literature

• Histidine protein methyltransferase 1 homolog 3 shared papers
• Large ribosomal subunit protein uL24 2 shared papers
• Large ribosomal subunit protein uL23 1 shared papers
• Unconventional myosin-Ia 1 shared papers
• Nucleolar protein 8 1 shared papers
• Nucleolar pre-ribosomal-associated protein 1 1 shared papers
• Glutamate-rich WD repeat-containing protein 1 2 shared papers
• Vacuolar fusion protein MON1 homolog A 1 shared papers
• ATP-dependent RNA helicase DDX18 1 shared papers
• Probable ATP-dependent RNA helicase DDX47 1 shared papers
• Large ribosomal subunit protein uL30 2 shared papers
• Large ribosomal subunit protein eL27 1 shared papers

Literature · 30 cited papers

• The Genetic Architecture of Congenital Diarrhea and Enteropathy. N. Engl. J. Med. · 2025
• METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. Elife · 2022
• Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function. Nucleic Acids Res. · 2021
• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• The DHX33 RNA Helicase Promotes mRNA Translation Initiation. Mol. Cell. Biol. · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• SUMO-2 orchestrates chromatin modifiers in response to DNA damage. Cell Rep. · 2015
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• … and 18 more in the literature graph