Large ribosomal subunit protein uL24

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00467 KOW, PF16906 Ribosomal_L26

InterPro

KOW, Rib_uL2_dom2, Ribosomal_uL24_CS, Ribosomal_uL24_euk_arc, Ribosomal_uL24_KOW, Translation_prot_SH3-like_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 156

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 144 more

A predicted model is available from AlphaFold.

Gene Ontology · 23

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:1990904 ribonucleoprotein complex
• GO:0048027 mRNA 5'-UTR binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0071480 cellular response to gamma radiation
• GO:0034644 cellular response to UV
• GO:0002181 cytoplasmic translation
• GO:0030330 DNA damage response, signal transduction by p53 class mediator
• GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
• GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• GO:0045727 positive regulation of translation
• GO:1904803 regulation of translation involved in cellular response to UV
• GO:0042273 ribosomal large subunit biogenesis
• GO:0006364 rRNA processing
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 11 MONDO:0013964

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Large ribosomal subunit protein uL24 1.00
• Ribosomal protein uL24-like 1.00
• Large ribosomal subunit protein uL24 0.98
• Large ribosomal subunit protein uL24 0.97
• Large ribosomal subunit protein eL21 0.84
• Large ribosomal subunit protein eL21 0.84
• Large ribosomal subunit protein eL21 0.83
• Large ribosomal subunit protein eL21 0.83
• Large ribosomal subunit protein eL21 0.83

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL6 1 shared papers
• Large ribosomal subunit protein uL23 1 shared papers
• Large ribosomal subunit protein uL3 2 shared papers
• Large ribosomal subunit protein eL27 1 shared papers
• Eukaryotic translation initiation factor 3 subunit G 1 shared papers
• Large ribosomal subunit protein uL24 1 shared papers
• Large ribosomal subunit protein uL30 1 shared papers
• Eukaryotic translation initiation factor 3 subunit H 1 shared papers
• Large ribosomal subunit protein uL3 1 shared papers
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 shared papers
• ATP-dependent RNA helicase DHX33 1 shared papers
• Large ribosomal subunit protein uL30 1 shared papers

Literature · 16 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation. Cell · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• The DHX33 RNA Helicase Promotes mRNA Translation Initiation. Mol. Cell. Biol. · 2015
• SUMO-2 orchestrates chromatin modifiers in response to DNA damage. Cell Rep. · 2015
• System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. Mol. Cell. Proteomics · 2015
• Uncovering global SUMOylation signaling networks in a site-specific manner. Nat. Struct. Mol. Biol. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum. Mutat. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• … and 4 more in the literature graph