Large ribosomal subunit protein uL23

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination.

Classification

Family (Pfam)

PF00276 Ribosomal_L23, PF03939 Ribosomal_L23eN

InterPro

Nucleotide-bd_a/b_plait_sf, Ribosomal_uL23, Ribosomal_uL23-like, Ribosomal_uL23/eL15/eS24_sf, Ribosomal_uL23_CS, Ribosomal_uL23_N

Functional cluster

Small/Large Ribosomal Subunit Proteins

Experimental structures · PDB · 157

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 145 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005730 nucleolus
• GO:0005634 nucleus
• GO:0045296 cadherin binding
• GO:0003723 RNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:1904841 TORC2 complex binding
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL23 1.00
• Large ribosomal subunit protein uL23 1.00
• Large ribosomal subunit protein uL23 1.00
• Large ribosomal subunit protein uL23y 0.89
• Large ribosomal subunit protein uL23 0.88
• Large ribosomal subunit protein uL23z 0.87
• Large ribosomal subunit protein uL23A 0.86
• Large ribosomal subunit protein uL23 0.85
• Large ribosomal subunit protein uL23 0.85
• Large ribosomal subunit protein uL23 0.84
• Large ribosomal subunit protein uL23A 0.82
• Large ribosomal subunit protein uL23 0.82

Co-cited proteins · studied together in the literature

• Nucleolar GTP-binding protein 2 1 shared papers
• Large ribosomal subunit protein uL24 1 shared papers
• Cell growth-regulating nucleolar protein 1 shared papers
• Large ribosomal subunit protein uL3 1 shared papers
• Importin-5 2 shared papers
• Importin-7 2 shared papers
• Transportin-1 2 shared papers
• Importin-8 1 shared papers
• Signal recognition particle 19 kDa protein 1 shared papers
• Small ribosomal subunit protein eS7 1 shared papers
• Importin subunit beta-1 2 shared papers
• Large ribosomal subunit protein uL18 1 shared papers

Literature · 20 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• Nucleolar GTP-binding protein-1 (NGP-1) promotes G1 to S phase transition by activating cyclin-dependent kinase inhibitor p21 Cip1/Waf1. J. Biol. Chem. · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum. Mutat. · 2012
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• … and 8 more in the literature graph