Small ribosomal subunit protein eS7
Also known as: RPS7
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Classification
- Family (Pfam)
- PF01251 Ribosomal_S7e
- InterPro
- Ribosomal_eS7, Ribosomal_eS7_CS
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Experimental structures · PDB · 176
- 4UG0 EM
- 4V6X EM 5.00A
- 5A2Q EM 3.90A
- 5AJ0 EM 3.50A
- 5FLX EM 3.90A
- 5LKS EM 3.60A
- 5OA3 EM 4.30A
- 5T2C EM 3.60A
- 5VYC X-ray 6.00A
- 6FEC EM 6.30A
- 6G18 EM 3.60A
- 6G4S EM 4.00A
- … and 164 more
A predicted model is available from AlphaFold.
Gene Ontology · 27
- GO:0005813 centrosome
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0022626 cytosolic ribosome
- GO:0022627 cytosolic small ribosomal subunit
- GO:0005925 focal adhesion
- GO:0016020 membrane
- GO:0005730 nucleolus
- GO:0005654 nucleoplasm
- GO:0005634 nucleus
- GO:0032991 protein-containing complex
- GO:1990904 ribonucleoprotein complex
- GO:0005840 ribosome
- GO:0032040 small-subunit processome
- GO:0045202 synapse
- GO:0003730 mRNA 3'-UTR binding
- GO:0048027 mRNA 5'-UTR binding
- GO:0019901 protein kinase binding
- GO:0003723 RNA binding
- GO:0003735 structural constituent of ribosome
- GO:1990948 ubiquitin ligase inhibitor activity
- GO:0002181 cytoplasmic translation
- GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
- GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
- GO:0042274 ribosomal small subunit biogenesis
- GO:0006364 rRNA processing
- GO:0006412 translation
Disease associations
- Diamond-Blackfan anemia 8 MONDO:0012939
Drugs targeting this protein · 2
- CYCLOHEXIMIDE inhibitor
- ATALUREN modulator
Related proteins · sequence + function similarity
- Small ribosomal subunit protein eS7 1.00
- Small ribosomal subunit protein eS7 1.00
- Small ribosomal subunit protein eS7 1.00
- Small ribosomal subunit protein eS7 1.00
- Small ribosomal subunit protein eS7 1.00
- Small ribosomal subunit protein eS7 0.99
- Small ribosomal subunit protein eS7 0.99
- Small ribosomal subunit protein eS7 0.99
- Eukaryotic translation initiation factor 1 0.80
- Eukaryotic translation initiation factor 1 0.80
- Eukaryotic translation initiation factor 1 0.80
- Eukaryotic translation initiation factor 1 0.79
Co-cited proteins · studied together in the literature
- Deubiquitinase DESI2 1 shared papers
- Small ribosomal subunit protein eS17 2 shared papers
- Large ribosomal subunit protein uL18 2 shared papers
- Large ribosomal subunit protein uL5 1 shared papers
- Importin-4 1 shared papers
- Large ribosomal subunit protein eL20 1 shared papers
- Large ribosomal subunit protein eL6 1 shared papers
- Large ribosomal subunit protein uL23 1 shared papers
- Rho GTPase-activating protein 33 1 shared papers
- Importin-5 1 shared papers
- Small ribosomal subunit protein eS1 1 shared papers
- Large ribosomal subunit protein uL4 1 shared papers
Literature · 23 cited papers
- Nucleolar maturation of the human small subunit processome. Science · 2021
- PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family. Biochem. Biophys. Res. Commun. · 2017
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Structures of the human and Drosophila 80S ribosome. Nature · 2013
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. · 2010
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
- … and 11 more in the literature graph
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