Large ribosomal subunit protein uL4

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF14374 Ribos_L4_asso_C, PF00573 Ribosomal_L4

InterPro

Ribos_uL4_C_dom, Ribosomal_uL4, Ribosomal_uL4_dom_sf, Ribosomal_uL4_euk_arc, Ribosomal_uL4_euk_arc_CS

Functional cluster

Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 158

• 4UG0 EM
• 4V6X EM 5.00A
• 5A8L EM 3.80A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• … and 146 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005634 nucleus
• GO:1990904 ribonucleoprotein complex
• GO:0005791 rough endoplasmic reticulum
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL4 1.00
• Large ribosomal subunit protein uL4 1.00
• Large ribosomal subunit protein uL4 0.99
• Large ribosomal subunit protein uL4 0.99
• Large ribosomal subunit protein uL4 0.99
• Large ribosomal subunit protein uL4 0.99
• Large ribosomal subunit protein uL4 0.99
• Large ribosomal subunit protein uL4B 0.97
• Large ribosomal subunit protein uL4A 0.96
• Large ribosomal subunit protein uL4 0.91
• Large ribosomal subunit protein uL4z 0.90
• Large ribosomal subunit protein uL4 0.88

Co-cited proteins · studied together in the literature

• Importin-4 1 shared papers
• Large ribosomal subunit protein eL20 1 shared papers
• Large ribosomal subunit protein eL6 1 shared papers
• Small ribosomal subunit protein eS1 1 shared papers
• Large ribosomal subunit protein uL4 1 shared papers
• Importin-9 1 shared papers
• Importin-9 1 shared papers
• Small ribosomal subunit protein eS7 1 shared papers
• Large ribosomal subunit protein eL6 1 shared papers
• Importin-4 1 shared papers
• Small ribosomal subunit protein eS1 1 shared papers
• Large ribosomal subunit protein eL31 1 shared papers

Literature · 20 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• … and 8 more in the literature graph