Large ribosomal subunit protein eL6

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01159 Ribosomal_L6e, PF03868 Ribosomal_L6e_N

InterPro

60S_ribosomal_eL6, Rib_uL2_dom2, Ribosomal_eL6_CS, Ribosomal_eL6_KOW, Ribosomal_uL6_N, Translation_prot_SH3-like_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 156

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 144 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:0005737 cytoplasm
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005634 nucleus
• GO:0014069 postsynaptic density
• GO:0005791 rough endoplasmic reticulum
• GO:0045296 cadherin binding
• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0006355 regulation of DNA-templated transcription
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL6 0.99
• Large ribosomal subunit protein eL6 0.99
• Large ribosomal subunit protein eL6 0.99
• Large ribosomal subunit protein eL6 0.97
• Large ribosomal subunit protein eL6 0.96
• Large ribosomal subunit protein eL6 0.95
• Large ribosomal subunit protein eL21 0.73
• Large ribosomal subunit protein eL21 0.72
• Large ribosomal subunit protein eL21 0.72
• Large ribosomal subunit protein eL21 0.72
• Large ribosomal subunit protein eL21 0.72
• Large ribosomal subunit protein eL21 0.72

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL6 1 shared papers
• Large ribosomal subunit protein uL24 1 shared papers
• Large ribosomal subunit protein eL36 3 shared papers
• Large ribosomal subunit protein eL18 3 shared papers
• Large ribosomal subunit protein eL34 3 shared papers
• Importin-4 1 shared papers
• Large ribosomal subunit protein eL20 1 shared papers
• Large ribosomal subunit protein eL6 1 shared papers
• Large ribosomal subunit protein eL27 3 shared papers
• Large ribosomal subunit protein eL21 3 shared papers
• Small ribosomal subunit protein eS21 2 shared papers
• Small ribosomal subunit protein uS12 2 shared papers

Literature · 19 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J. Proteome Res. · 2007
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 7 more in the literature graph