Large ribosomal subunit protein eL18

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF17135 Ribosomal_L18

InterPro

Ribosomal_eL18, Ribosomal_eL18/eL18-A/B/_CS, Ribosomal_uL15/eL18, Ribosomal_uL15/eL18_sf

Functional cluster

Ribosomal S8 & Metabolic Enzymes

Experimental structures · PDB · 157

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 145 more

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005634 nucleus
• GO:0005791 rough endoplasmic reticulum
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 18 MONDO:0032668

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL18 1.00
• Large ribosomal subunit protein eL18 1.00
• Large ribosomal subunit protein eL18 0.99
• Large ribosomal subunit protein eL18 0.99
• Large ribosomal subunit protein eL18 0.98
• Large ribosomal subunit protein eL18 0.96
• Large ribosomal subunit protein eL18 0.96
• Large ribosomal subunit protein eL18 0.94
• Large ribosomal subunit protein eL18B 0.94
• Large ribosomal subunit protein eL18 0.91
• Large ribosomal subunit protein eL18A 0.90
• Large ribosomal subunit protein eL18 0.82

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL29 2 shared papers
• Large ribosomal subunit protein eL36 4 shared papers
• Large ribosomal subunit protein eL34 4 shared papers
• Large ribosomal subunit protein eL27 4 shared papers
• Large ribosomal subunit protein eL6 3 shared papers
• Small ribosomal subunit protein eS21 3 shared papers
• Large ribosomal subunit protein eL21 4 shared papers
• Small ribosomal subunit protein eS28 3 shared papers
• Small ribosomal subunit protein uS14 3 shared papers
• Small ribosomal subunit protein uS12 2 shared papers
• Small ribosomal subunit protein eS26 2 shared papers
• Large ribosomal subunit protein uL11 1 shared papers

Literature · 22 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Novel and known ribosomal causes of Diamond-Blackfan anaemia identified through comprehensive genomic characterisation. J. Med. Genet. · 2017
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• … and 10 more in the literature graph