Large ribosomal subunit protein uL11

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA.

Classification

Family (Pfam)

PF00298 Ribosomal_L11, PF03946 Ribosomal_L11_N

InterPro

Ribosomal_uL11, Ribosomal_uL11_C, Ribosomal_uL11_C_sf, Ribosomal_uL11_CS, Ribosomal_uL11_N, Ribosomal_uL11_N_sf

Functional cluster

Small GTPases (Ras/Rab) & related

Experimental structures · PDB · 87

• 4V6X EM 5.00A
• 5A8L EM 3.80A
• 5AJ0 EM 3.50A
• 6OLG EM 3.40A
• 6ZM7 EM 2.70A
• 6ZME EM 3.00A
• 6ZMI EM 2.60A
• 6ZMO EM 3.10A
• 7VB2 NMR
• 8FKR EM 2.89A
• 8FKS EM 2.88A
• 8FKT EM 2.81A
• … and 75 more

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0014069 postsynaptic density
• GO:0070180 large ribosomal subunit rRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL11 1.00
• Large ribosomal subunit protein uL11 1.00
• Large ribosomal subunit protein uL11 1.00
• Large ribosomal subunit protein uL11 1.00
• Large ribosomal subunit protein uL11 0.99
• Large ribosomal subunit protein uL11 0.96
• Large ribosomal subunit protein uL11 0.96
• Large ribosomal subunit protein uL11 0.94
• Large ribosomal subunit protein uL11A 0.94
• Large ribosomal subunit protein uL11B 0.94
• Large ribosomal subunit protein uL11A 0.93
• Large ribosomal subunit protein uL11B 0.93

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS15 1 shared papers
• Small ribosomal subunit protein eS17 1 shared papers
• Ribosomal protein uL16-like 1 shared papers
• E3 ubiquitin-protein ligase RNF25 1 shared papers
• Large ribosomal subunit protein P1 1 shared papers
• Large ribosomal subunit protein eL36 1 shared papers
• Large ribosomal subunit protein uL10 1 shared papers
• Stalled ribosome sensor GCN1 1 shared papers
• Large ribosomal subunit protein eL18 1 shared papers
• Small ribosomal subunit protein eS21 1 shared papers
• E3 ubiquitin-protein ligase RNF14 1 shared papers
• Small ribosomal subunit protein uS12 1 shared papers

Literature · 20 cited papers

• An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell · 2023
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• … and 8 more in the literature graph