Large ribosomal subunit protein P1

Function

Plays an important role in the elongation step of protein synthesis.

Classification

Family (Pfam)

PF00428 Ribosomal_60s

InterPro

P1/P2_N_sf, Ribosomal_P1/P2

Functional cluster

Ribosomal Protein L12 & Acyl Carriers

Experimental structures · PDB · 3

• 2LBF NMR
• 4BEH NMR
• 4V6X EM 5.00A

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0005925 focal adhesion
• GO:0030295 protein kinase activator activity
• GO:0043021 ribonucleoprotein complex binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation
• GO:0006414 translational elongation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein P1 1.00
• Large ribosomal subunit protein P1 1.00
• Large ribosomal subunit protein P1 0.98
• Large ribosomal subunit protein P1 0.98
• Large ribosomal subunit protein P1 0.97
• Large ribosomal subunit protein P1 0.96
• Large ribosomal subunit protein P1 0.96
• Large ribosomal subunit protein P1 0.96
• Large ribosomal subunit protein P1 0.96
• Large ribosomal subunit protein P1 0.95
• Large ribosomal subunit protein P1 0.95
• Large ribosomal subunit protein P1 0.95

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein P2 3 shared papers
• Large ribosomal subunit protein uL10 2 shared papers
• Galanin peptides 2 shared papers
• Secretogranin-1 2 shared papers
• Chromogranin-A 2 shared papers
• Small ribosomal subunit protein uS15 1 shared papers
• Large ribosomal subunit protein uL11 1 shared papers
• Somatotropin 2 shared papers
• DnaJ homolog subfamily C member 5 1 shared papers
• Small ribosomal subunit protein eS17 1 shared papers
• E3 ubiquitin-protein ligase RNF25 1 shared papers
• Stalled ribosome sensor GCN1 1 shared papers

Literature · 14 cited papers

• An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell · 2023
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex. Nucleic Acids Res. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Phosphoproteomic analysis of the human pituitary. Pituitary · 2006
• Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Identification and characterization of phosphorylated proteins in the human pituitary. Proteomics · 2004
• … and 2 more in the literature graph