Small ribosomal subunit protein uS15

UniProt P62277 Organism Homo sapiens Gene RPS13

Also known as: RPS13

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF08069 Ribosomal_S13_N, PF00312 Ribosomal_S15
InterPro: Ribosomal_uS15, Ribosomal_uS15_arc_euk, Ribosomal_uS15_N, uS15_NS1_RNA-bd_sf
Functional cluster: Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 180

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 168 more

A predicted model is available from AlphaFold.

Gene Ontology · 22

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Large ribosomal subunit protein uL11 1 shared papers
Small ribosomal subunit protein eS17 2 shared papers
E3 ubiquitin-protein ligase RNF25 1 shared papers
Large ribosomal subunit protein P1 1 shared papers
Large ribosomal subunit protein uL10 1 shared papers
Stalled ribosome sensor GCN1 1 shared papers
E3 ubiquitin-protein ligase RNF14 1 shared papers
Small ribosomal subunit protein uS13 1 shared papers
Small ribosomal subunit protein eS24 1 shared papers
Eukaryotic peptide chain release factor subunit 1 1 shared papers
Ubiquitin-ribosomal protein eS31 fusion protein 2 shared papers
Small ribosomal subunit protein eS25 1 shared papers

Literature · 17 cited papers

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell · 2023
Nucleolar maturation of the human small subunit processome. Science · 2021
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat. Biotechnol. · 2005
… and 5 more in the literature graph

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