Small ribosomal subunit protein eS17

UniProt P08708 Organism Homo sapiens Gene RPS17, RPS17L

Also known as: RPS17, RPS17L

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF00833 Ribosomal_S17e
InterPro: Ribosomal_eS17, Ribosomal_eS17_CS, Ribosomal_eS17_sf
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 179

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 167 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

Disease associations

Diamond-Blackfan anemia 4 MONDO:0012924

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein eS17 1 shared papers
Small ribosomal subunit protein uS11 2 shared papers
Small ribosomal subunit protein eS7 2 shared papers
Large ribosomal subunit protein uL5 1 shared papers
Large ribosomal subunit protein uL18 1 shared papers
Small ribosomal subunit protein uS15 2 shared papers
Large ribosomal subunit protein uL11 1 shared papers
E3 ubiquitin-protein ligase RNF25 1 shared papers
Large ribosomal subunit protein P1 1 shared papers
Large ribosomal subunit protein uL10 1 shared papers
Stalled ribosome sensor GCN1 1 shared papers
E3 ubiquitin-protein ligase RNF14 1 shared papers

Literature · 23 cited papers

An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell · 2023
Nucleolar maturation of the human small subunit processome. Science · 2021
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
… and 11 more in the literature graph

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