Large ribosomal subunit protein uL10

Function

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Classification

Family (Pfam)

PF00428 Ribosomal_60s, PF00466 Ribosomal_L10, PF17777 RL10P_insert

InterPro

Ribosomal_protein_uL10, Ribosomal_uL10, Ribosomal_uL10-like_insert, Ribosomal_uL10-like_insert_sf, Ribosomal_uL10-like_sf, uL10_euk

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 57

• 4V6W EM 6.00A
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 6OLG EM 3.40A
• 6ZM7 EM 2.70A
• 6ZME EM 3.00A
• 6ZMI EM 2.60A
• 6ZMO EM 3.10A
• 8G5Z EM 2.64A
• 8G60 EM 2.54A
• 8G6J EM 2.80A
• 8K2C EM 2.40A
• … and 45 more

A predicted model is available from AlphaFold.

Gene Ontology · 21

• GO:0005737 cytoplasm
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005634 nucleus
• GO:0098794 postsynapse
• GO:0014069 postsynaptic density
• GO:1990904 ribonucleoprotein complex
• GO:0070180 large ribosomal subunit rRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0042254 ribosome biogenesis
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL10 1.00
• Large ribosomal subunit protein uL10 1.00
• Large ribosomal subunit protein uL10 1.00
• Large ribosomal subunit protein uL10 1.00
• Large ribosomal subunit protein uL10 1.00
• Putative ribosomal protein uL10-like 1.00
• Large ribosomal subunit protein uL10 0.98
• Large ribosomal subunit protein uL10 0.96
• Large ribosomal subunit protein uL10 0.91
• Eukaryotic translation initiation factor 2 subunit 3 0.76
• Eukaryotic translation initiation factor 2 subunit 3 0.76
• Eukaryotic translation initiation factor 2 subunit 3 0.76

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein P1 2 shared papers
• Large ribosomal subunit protein P2 1 shared papers
• Cytoplasmic FMR1-interacting protein 2 1 shared papers
• Eukaryotic translation initiation factor 5 1 shared papers
• Small ribosomal subunit protein uS15 1 shared papers
• Large ribosomal subunit protein uL11 1 shared papers
• Peroxiredoxin-6 1 shared papers
• Nucleolin 2 shared papers
• Small ribosomal subunit protein eS17 1 shared papers
• Methylosome protein WDR77 1 shared papers
• E3 ubiquitin-protein ligase RNF25 1 shared papers
• Fragile X messenger ribonucleoprotein 1 1 shared papers

Literature · 16 cited papers

• An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell · 2023
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS ONE · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol. Cell. Biol. · 2009
• Molecular composition of IMP1 ribonucleoprotein granules. Mol. Cell. Proteomics · 2007
• … and 4 more in the literature graph