Large ribosomal subunit protein eL21

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01157 Ribosomal_L21e

InterPro

Ribosomal_eL21, Ribosomal_eL21_CS, Ribosomal_eL21_sf, Translation_prot_SH3-like_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 155

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 143 more

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0001650 fibrillar center
• GO:0016020 membrane
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Disease associations

• hypotrichosis 12 MONDO:0014384

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL21 1.00
• Large ribosomal subunit protein eL21 1.00
• Large ribosomal subunit protein eL21 1.00
• Large ribosomal subunit protein eL21 1.00
• Large ribosomal subunit protein eL21 0.99
• Large ribosomal subunit protein uL24 0.84
• Large ribosomal subunit protein uL24 0.83
• Large ribosomal subunit protein uL24 0.83
• Large ribosomal subunit protein uL24 0.83
• Large ribosomal subunit protein uL24 0.83
• Large ribosomal subunit protein uL24 0.83
• Ribosomal protein uL24-like 0.82

Co-cited proteins · studied together in the literature

• Proteasome activator complex subunit 3 1 shared papers
• ADP-ribosylation factor-like protein 4D 1 shared papers
• Ras-related protein Rab-5C 1 shared papers
• Small ribosomal subunit protein uS14 5 shared papers
• Large ribosomal subunit protein eL28 2 shared papers
• Large ribosomal subunit protein eL36 4 shared papers
• Large ribosomal subunit protein eL34 5 shared papers
• Large ribosomal subunit protein eL18 4 shared papers
• Small ribosomal subunit protein eS21 4 shared papers
• Small ribosomal subunit protein uS7 3 shared papers
• Small ribosomal subunit protein eS28 4 shared papers
• Large ribosomal subunit protein eL27 4 shared papers

Literature · 16 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex. Hum. Mutat. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J. Protein Chem. · 2003
• The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res. · 2002
• … and 4 more in the literature graph