Proteasome activator complex subunit 3

UniProt P61289 Organism Homo sapiens Gene PSME3

Also known as: PSME3

Function

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.

Classification

Family (Pfam): PF02252 PA28_C, PF02251 PA28_N
InterPro: PA28_C, PA28_C_sf, PA28_N_sf, Proteasome_activ_PA28, Proteasome_activ_PA28_N, Proteasome_activ_sf
Functional cluster: Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 2

7YQC EM 2.82A
7YQD EM 3.40A

A predicted model is available from AlphaFold.

Gene Ontology · 18

Neighborhood · nearest proteins

Nearest neighbours of Proteasome activator complex subunit 3: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Protein UL27 1 shared papers
PSME3-interacting protein 1 shared papers
Ras-related protein Rab-5C 1 shared papers
E1A-binding protein p400 1 shared papers
Large ribosomal subunit protein eL21 1 shared papers
Coilin 1 shared papers
Breast cancer type 1 susceptibility protein 1 shared papers
Cell cycle and apoptosis regulator protein 2 1 shared papers
Serine/threonine-protein kinase Chk2 1 shared papers
NAD-dependent protein deacetylase sirtuin-1 1 shared papers

Literature · 26 cited papers

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28gamma. Proc. Natl. Acad. Sci. U.S.A. · 2018
Chk2 and REGgamma-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res. · 2014
Site-specific acetylation of the proteasome activator REGgamma directs its heptameric structure and functions. J. Biol. Chem. · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent proteasomal degradation of Tip60 acetyltransferase and cell-cycle arrest. Cell Host Microbe · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation. EMBO J. · 2008
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry · 2007
… and 14 more in the literature graph

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