Small ribosomal subunit protein eS28

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam)

PF01200 Ribosomal_S28e

InterPro

NA-bd_OB-fold, Ribosomal_eS28, Ribosomal_eS28_CS

Functional cluster

ABC Transporter ATPases & DnaJ Chaperones

Experimental structures · PDB · 177

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6FEC EM 6.30A
• 6G18 EM 3.60A
• 6G4S EM 4.00A
• … and 165 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
• GO:0005829 cytosol
• GO:0022627 cytosolic small ribosomal subunit
• GO:0070062 extracellular exosome
• GO:0005654 nucleoplasm
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0030490 maturation of SSU-rRNA
• GO:0000028 ribosomal small subunit assembly
• GO:0042274 ribosomal small subunit biogenesis
• GO:0042254 ribosome biogenesis
• GO:0006364 rRNA processing
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 15 with mandibulofacial dysostosis MONDO:0011639

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS28 1.00
• Small ribosomal subunit protein eS28 1.00
• Small ribosomal subunit protein eS28 1.00
• Small ribosomal subunit protein eS28 1.00
• Small ribosomal subunit protein eS28 0.98
• Small ribosomal subunit protein eS28 0.98
• Small ribosomal subunit protein eS28 0.91
• Small ribosomal subunit protein eS28 0.91
• Small ribosomal subunit protein eS28 0.91
• Small ribosomal subunit protein eS28z/eS28y 0.90
• Small ribosomal subunit protein eS28x 0.89
• Small ribosomal subunit protein eS28 0.89

Co-cited proteins · studied together in the literature

• Pre-rRNA-processing protein TSR2 homolog 1 shared papers
• Small ribosomal subunit protein eS26 4 shared papers
• Small ribosomal subunit protein eS21 5 shared papers
• Large ribosomal subunit protein eL36 3 shared papers
• Small ribosomal subunit protein uS14 5 shared papers
• Large ribosomal subunit protein eL34 4 shared papers
• Small ribosomal subunit protein uS12 4 shared papers
• Large ribosomal subunit protein eL18 3 shared papers
• Large ribosomal subunit protein eL21 4 shared papers
• Large ribosomal subunit protein eL27 3 shared papers
• Large ribosomal subunit protein eL6 2 shared papers
• Large ribosomal subunit protein uL11 1 shared papers

Literature · 14 cited papers

• Nucleolar maturation of the human small subunit processome. Science · 2021
• Structural snapshots of actively translating human ribosomes. Cell · 2015
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Structure of the human 80S ribosome. Nature · 2015
• Diamond-Blackfan anemia with mandibulofacial dystostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28. Am. J. Med. Genet. A · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res. · 2002
• … and 2 more in the literature graph