Small ribosomal subunit protein eS1

UniProt P61247 Organism Homo sapiens Gene FTE1, MFTL, RPS3A

Also known as: FTE1, MFTL, RPS3A

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity).

Classification

Family (Pfam): PF01015 Ribosomal_S3Ae
InterPro: Ribosomal_eS1, Ribosomal_eS1_CS, Ribosomal_eS1_euk
Functional cluster: Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 179

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 167 more

A predicted model is available from AlphaFold.

Gene Ontology · 21

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein eS1 2 shared papers
Small ribosomal subunit protein eS1 2 shared papers
Histone PARylation factor 1 1 shared papers
Importin-4 1 shared papers
Large ribosomal subunit protein eL20 1 shared papers
Large ribosomal subunit protein eL6 1 shared papers
Large ribosomal subunit protein uL4 1 shared papers
Large ribosomal subunit protein uL4 1 shared papers
Poly [ADP-ribose] polymerase 1 1 shared papers
Importin-9 1 shared papers
Small ribosomal subunit protein eS7 2 shared papers
Importin-9 1 shared papers

Literature · 32 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site. EMBO Rep. · 2018
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. Mol. Cell. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
… and 20 more in the literature graph

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