Small ribosomal subunit protein eS12

UniProt P25398 Organism Homo sapiens Gene RPS12

Also known as: RPS12

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Subunit of the 40S ribosomal complex (By similarity).

Classification

Family (Pfam): PF01248 Ribosomal_L7Ae
InterPro: Ribosomal_eL30-like_sf, Ribosomal_eL8/eL30/eS12/Gad45, Ribosomal_eS12, Ribosomal_eS12_CS
Functional cluster: S-Adenosylmethionine Synthases & related

Experimental structures · PDB · 164

4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G51 EM 4.10A
6G53 EM 4.50A
… and 152 more

A predicted model is available from AlphaFold.

Gene Ontology · 14

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Large ribosomal subunit protein uL14 2 shared papers
Small ribosomal subunit protein uS7 3 shared papers
Small ribosomal subunit protein eS25 2 shared papers
Small ribosomal subunit protein uS9 2 shared papers
Small ribosomal subunit protein eS21 3 shared papers
Small ribosomal subunit protein eS27 3 shared papers
Small ribosomal subunit protein uS4 3 shared papers
Small ribosomal subunit protein eS28 3 shared papers
Large ribosomal subunit protein eL24 2 shared papers
Large ribosomal subunit protein uL22 2 shared papers
Large ribosomal subunit protein eL37 2 shared papers
Small ribosomal subunit protein uS14 3 shared papers

Literature · 18 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
… and 6 more in the literature graph

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