Large ribosomal subunit protein uL14

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00238 Ribosomal_L14

InterPro

Ribosomal_uL14, Ribosomal_uL14_CS, Ribosomal_uL14_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 152

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 140 more

A predicted model is available from AlphaFold.

Gene Ontology · 32

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005654 nucleoplasm
• GO:0032991 protein-containing complex
• GO:0005840 ribosome
• GO:0045202 synapse
• GO:0070180 large ribosomal subunit rRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0001223 transcription coactivator binding
• GO:1990948 ubiquitin ligase inhibitor activity
• GO:0031625 ubiquitin protein ligase binding
• GO:0002181 cytoplasmic translation
• GO:0070314 G1 to G0 transition
• GO:1901740 negative regulation of myoblast fusion
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
• GO:0008284 positive regulation of cell population proliferation
• GO:1901798 positive regulation of signal transduction by p53 class mediator
• GO:0050821 protein stabilization
• GO:0032986 protein-DNA complex disassembly
• GO:1903450 regulation of G1 to G0 transition
• GO:0006610 ribosomal protein import into nucleus
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 1.00
• Large ribosomal subunit protein uL14 0.99
• Large ribosomal subunit protein uL14 0.98
• Large ribosomal subunit protein uL14x/uL14z/uL14y 0.98
• Large ribosomal subunit protein uL14 0.94

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein eS12 2 shared papers
• Large ribosomal subunit protein eL31 1 shared papers
• Large ribosomal subunit protein eL32 1 shared papers
• Large ribosomal subunit protein eL30 1 shared papers
• Large ribosomal subunit protein uL4 1 shared papers
• Small ribosomal subunit protein eS25 1 shared papers
• Small ribosomal subunit protein uS9 1 shared papers
• Large ribosomal subunit protein eL14 1 shared papers
• Large ribosomal subunit protein eL24 1 shared papers
• Large ribosomal subunit protein eL39 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Large ribosomal subunit protein eL37 1 shared papers

Literature · 12 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat. Biotechnol. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res. · 2002
• Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein. Gene · 1991
• cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. Nucleic Acids Res. · 1991