Large ribosomal subunit protein eL14

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01929 Ribosomal_L14e

InterPro

Rib_uL2_dom2, Ribosomal_eL14, Ribosomal_eL14_dom, Translation_prot_SH3-like_sf

Functional cluster

Photosystem II Reaction-Center & Antimicrobial Peptides

Experimental structures · PDB · 154

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 142 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0014069 postsynaptic density
• GO:0045296 cadherin binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0042273 ribosomal large subunit biogenesis
• GO:0006364 rRNA processing
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL14 0.98
• Large ribosomal subunit protein eL14 0.97
• Large ribosomal subunit protein eL14 0.97
• Large ribosomal subunit protein eL14 0.97
• Large ribosomal subunit protein eL14 0.96
• Large ribosomal subunit protein eL14y 0.65
• Large ribosomal subunit protein eL14 0.63
• Large ribosomal subunit protein eL14z 0.63
• Large ribosomal subunit protein eL6 0.60
• Large ribosomal subunit protein eL6 0.59
• Large ribosomal subunit protein eL6 0.58
• Large ribosomal subunit protein eL6 0.57

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL36 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein eL22 1 shared papers
• Large ribosomal subunit protein eL39 1 shared papers
• Large ribosomal subunit protein uL29 2 shared papers
• Large ribosomal subunit protein eL39 2 shared papers
• Large ribosomal subunit protein eL29 1 shared papers
• Large ribosomal subunit protein uL22 2 shared papers
• Large ribosomal subunit protein eL36 2 shared papers
• Large ribosomal subunit protein eL18 2 shared papers
• Large ribosomal subunit protein uL2 2 shared papers
• Large ribosomal subunit protein eL28 1 shared papers

Literature · 25 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Uncovering global SUMOylation signaling networks in a site-specific manner. Nat. Struct. Mol. Biol. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• … and 13 more in the literature graph