Large ribosomal subunit protein uL22

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00237 Ribosomal_L22

InterPro

Ribosomal_uL22, Ribosomal_uL22_arc, Ribosomal_uL22_CS, Ribosomal_uL22_euk_arc, Ribosomal_uL22_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 155

• 4UG0 EM
• 4V6X EM 5.00A
• 5A8L EM 3.80A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• … and 143 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0005634 nucleus
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 22 MONDO:0979244

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 0.94
• Large ribosomal subunit protein uL22 0.94
• Large ribosomal subunit protein uL22 0.92
• Large ribosomal subunit protein uL22 0.92
• Large ribosomal subunit protein uL22 0.92
• Large ribosomal subunit protein uL22 0.92
• Large ribosomal subunit protein uL22 0.92

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL2 3 shared papers
• Large ribosomal subunit protein eL29 1 shared papers
• Large ribosomal subunit protein eL14 2 shared papers
• Large ribosomal subunit protein eL34 3 shared papers
• Large ribosomal subunit protein uL16 2 shared papers
• Large ribosomal subunit protein eL36 2 shared papers
• Large ribosomal subunit protein eL21 3 shared papers
• Large ribosomal subunit protein eL24 2 shared papers
• Large ribosomal subunit protein eL37 2 shared papers
• Large ribosomal subunit protein eL18 2 shared papers
• Large ribosomal subunit protein eL28 1 shared papers
• Large ribosomal subunit protein eL38 1 shared papers

Literature · 12 cited papers

• An atypical form of 60S ribosomal subunit in Diamond-Blackfan anemia linked to RPL17 variants. JCI Insight · 2024
• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• DNA sequence and analysis of human chromosome 18. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J. Protein Chem. · 2003
• The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. Genome Res. · 2002
• A map of 75 human ribosomal protein genes. Genome Res. · 1998
• A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui. Nucleic Acids Res. · 1990
• Isolation and characterization of a complementary DNA (PD-1) differentially expressed by human pancreatic ductal cell tumors. Cell Growth Differ. · 1991