Large ribosomal subunit protein eL37

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01907 Ribosomal_L37e

InterPro

Ribosomal_eL37, Ribosomal_eL37/eL43, Ribosomal_eL37_CS, Ribosomal_zn-bd

Functional cluster

Bacterial Ribosomal Proteins

Experimental structures · PDB · 153

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 141 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:0097371 MDM2/MDM4 family protein binding
• GO:0003723 RNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:1990948 ubiquitin ligase inhibitor activity
• GO:0008270 zinc ion binding
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:1901798 positive regulation of signal transduction by p53 class mediator
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL37 1.00
• Large ribosomal subunit protein eL37 1.00
• Large ribosomal subunit protein eL37 1.00
• Large ribosomal subunit protein eL37 0.98
• Large ribosomal subunit protein eL37 0.94
• Large ribosomal subunit protein eL37A 0.93
• Large ribosomal subunit protein eL37 0.92
• Large ribosomal subunit protein eL37A 0.91
• Large ribosomal subunit protein eL37 0.90
• Large ribosomal subunit protein eL37A 0.89
• Large ribosomal subunit protein eL37B 0.89
• Large ribosomal subunit protein eL37B 0.89

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL37 1 shared papers
• Large ribosomal subunit protein eL37 1 shared papers
• Large ribosomal subunit protein eL24 2 shared papers
• Large ribosomal subunit protein uL22 2 shared papers
• Large ribosomal subunit protein eL38 1 shared papers
• Large ribosomal subunit protein uL6 1 shared papers
• Small ribosomal subunit protein uS7 2 shared papers
• Small ribosomal subunit protein eS12 2 shared papers
• Large ribosomal subunit protein eL31 1 shared papers
• Large ribosomal subunit protein eL32 1 shared papers
• Large ribosomal subunit protein eL30 1 shared papers
• Small ribosomal subunit protein eS21 2 shared papers

Literature · 16 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 4 more in the literature graph