Small ribosomal subunit protein uS10

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00338 Ribosomal_S10

InterPro

Ribosomal_uS10, Ribosomal_uS10_CS, Ribosomal_uS10_dom, Ribosomal_uS10_dom_sf, Ribosomal_uS10_euk/arc

Functional cluster

Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 162

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5FLX EM 3.90A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5T2C EM 3.60A
• 5VYC X-ray 6.00A
• 6FEC EM 6.30A
• 6G51 EM 4.10A
• 6G53 EM 4.50A
• … and 150 more

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0005654 nucleoplasm
• GO:0045202 synapse
• GO:0097371 MDM2/MDM4 family protein binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:1990948 ubiquitin ligase inhibitor activity
• GO:0002181 cytoplasmic translation
• GO:1901798 positive regulation of signal transduction by p53 class mediator
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS10 1.00
• Small ribosomal subunit protein uS10 1.00
• Small ribosomal subunit protein uS10 1.00
• Small ribosomal subunit protein uS10 1.00
• Small ribosomal subunit protein uS10 1.00
• Small ribosomal subunit protein uS10 1.00
• Small ribosomal subunit protein uS10 0.99
• Small ribosomal subunit protein uS10 0.99
• Small ribosomal subunit protein uS10 0.95
• Small ribosomal subunit protein uS10y 0.94
• Small ribosomal subunit protein uS10 0.94
• Small ribosomal subunit protein uS10z/uS10x 0.93

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL43 1 shared papers
• Small ribosomal subunit protein eS10 7 shared papers
• E3 ubiquitin-protein ligase ZNF598 4 shared papers
• Small ribosomal subunit protein uS3 5 shared papers
• Small ribosomal subunit protein uS5 3 shared papers
• OTU domain-containing protein 3 1 shared papers
• Ubiquitin-conjugating enzyme E2 D3 1 shared papers
• Ubiquitin carboxyl-terminal hydrolase 21 1 shared papers
• Activating signal cointegrator 1 complex subunit 2 1 shared papers
• Activating signal cointegrator 1 complex subunit 3 1 shared papers
• Activating signal cointegrator 1 1 shared papers
• Small ribosomal subunit protein uS7 3 shared papers

Literature · 19 cited papers

• A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. Nat. Commun. · 2022
• Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized. Elife · 2020
• The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nat. Commun. · 2017
• ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation. Mol. Cell · 2017
• Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination. Mol. Cell · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• … and 7 more in the literature graph