Large ribosomal subunit protein eL43

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01780 Ribosomal_L37ae

InterPro

Ribosomal_eL37/eL43, Ribosomal_eL43, Ribosomal_zn-bd

Functional cluster

Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 143

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 131 more

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0005634 nucleus
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0008270 zinc ion binding
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL43 1.00
• Large ribosomal subunit protein eL43 1.00
• Large ribosomal subunit protein eL43 1.00
• Large ribosomal subunit protein eL43 1.00
• Large ribosomal subunit protein eL43 1.00
• Large ribosomal subunit protein eL43 0.99
• Large ribosomal subunit protein eL43 0.98
• Large ribosomal subunit protein eL43 0.95
• Putative ribosomal protein eL43-like 0.86
• Large ribosomal subunit protein eL43 0.83
• Large ribosomal subunit protein eL43 0.83
• Large ribosomal subunit protein eL43 0.82

Co-cited proteins · studied together in the literature

• Small ribosomal subunit protein uS10 1 shared papers

Literature · 11 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Human ribosomal protein S20 cDNA sequence. Nucleic Acids Res. · 1993
• Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines. Gene · 1993
• Primary sequence of the human ribosomal protein L37a. Nucleic Acids Res. · 1992