Large ribosomal subunit protein uL1

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00687 Ribosomal_L1

InterPro

eL8/uL1-like, Ribosomal_uL1, Ribosomal_uL1-like, Ribosomal_uL1/biogenesis, Ribosomal_uL1_3-a/b-sand, Ribosomal_uL1_CS

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 68

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LU8 EM 3.13A
• 6OLG EM 3.40A
• 6QZP EM 2.90A
• 6Y6X EM 2.80A
• … and 56 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005634 nucleus
• GO:0014069 postsynaptic density
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0045471 response to ethanol
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL1 1.00
• Large ribosomal subunit protein uL1 1.00
• Large ribosomal subunit protein uL1 1.00
• Large ribosomal subunit protein uL1 1.00
• Large ribosomal subunit protein uL1 0.97
• Large ribosomal subunit protein uL1 0.96
• Large ribosomal subunit protein uL1 0.94
• Large ribosomal subunit protein uL1 0.93
• Large ribosomal subunit protein uL1 0.92
• Large ribosomal subunit protein uL1 0.92
• Large ribosomal subunit protein uL1z 0.90
• Large ribosomal subunit protein uL1y 0.89

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein uL1 1 shared papers
• DDRGK domain-containing protein 1 1 shared papers
• Ubiquitin-fold modifier-conjugating enzyme 1 1 shared papers
• CDK5 regulatory subunit-associated protein 3 1 shared papers
• Large ribosomal subunit protein eL29 1 shared papers
• E3 UFM1-protein ligase 1 1 shared papers
• Large ribosomal subunit protein eL28 1 shared papers
• Large ribosomal subunit protein eL14 1 shared papers
• Large ribosomal subunit protein uL29 1 shared papers
• Large ribosomal subunit protein uL30 1 shared papers
• Large ribosomal subunit protein uL22 1 shared papers
• Large ribosomal subunit protein uL16 1 shared papers

Literature · 16 cited papers

• The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Nature · 2024
• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 4 more in the literature graph