Small ribosomal subunit protein uS17

UniProt P62280 Organism Homo sapiens Gene RPS11

Also known as: RPS11

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Classification

Family (Pfam): PF00366 Ribosomal_S17, PF16205 Ribosomal_S17_N
InterPro: NA-bd_OB-fold, Ribosomal_uS17, Ribosomal_uS17_arc/euk, Ribosomal_uS17_CS, Ribosomal_uS17_N
Functional cluster: Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 175

4UG0 EM
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
6G18 EM 3.60A
6G4S EM 4.00A
… and 163 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein uS17 1 shared papers
Large ribosomal subunit protein uL13 1 shared papers
Glutathione S-transferase 3, mitochondrial 1 shared papers
Synaptosomal-associated protein 23 1 shared papers
Guanine nucleotide-binding protein subunit alpha-11 1 shared papers
Protein transport protein Sec61 subunit beta 1 shared papers
Large ribosomal subunit protein eL38 1 shared papers
Large ribosomal subunit protein uL6 1 shared papers
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 shared papers
Small ribosomal subunit protein uS7 2 shared papers
Small ribosomal subunit protein uS8 2 shared papers
Small ribosomal subunit protein eS12 2 shared papers

Literature · 18 cited papers

Nucleolar maturation of the human small subunit processome. Science · 2021
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Structures of the human and Drosophila 80S ribosome. Nature · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Site-specific analysis of protein S-acylation by resin-assisted capture. J. Lipid Res. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
… and 6 more in the literature graph

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