Guanine nucleotide-binding protein subunit alpha-11

UniProt P29992 Organism Homo sapiens Gene GA11, GNA11 EC 3.6.5.-

Also known as: GA11, GNA11

Function

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens.

Classification

Family (Pfam): PF00503 G-alpha
InterPro: Gprotein_alpha_Q, Gprotein_alpha_su, GproteinA_insert, P-loop_NTPase
Functional cluster: Small GTPases (Ras/Rab) & related

Experimental structures · PDB · 8

6OIJ EM 3.30A
7RKF EM 4.00A
7TRY EM 3.70A
7XXH EM 2.90A
8QEG X-ray 1.70A
8QEH X-ray 1.43A
9UAP EM 3.62A
9UCP EM 2.88A

A predicted model is available from AlphaFold.

Gene Ontology · 25

Disease associations

familial hypocalciuric hypercalcemia 2 MONDO:0007792
autosomal dominant hypocalcemia 2 MONDO:0014146

Neighborhood · nearest proteins

Nearest neighbours of Guanine nucleotide-binding protein subunit alpha-11: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Neurotensin receptor type 1 1 shared papers
Guanine nucleotide-binding protein G(q) subunit alpha 3 shared papers
2-oxoglutarate receptor 1 1 shared papers
2-oxoglutarate receptor 1 1 shared papers
Regulator of G protein signaling 22 1 shared papers
Regulator of G protein signaling 22 1 shared papers
Free fatty acid receptor 4 1 shared papers
Free fatty acid receptor 4 1 shared papers
Glutathione S-transferase 3, mitochondrial 1 shared papers
Small ribosomal subunit protein uS17 1 shared papers
G protein-coupled receptor homolog US27 1 shared papers
G protein-coupled receptor homolog US28 1 shared papers

Literature · 15 cited papers

The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response. J. Clin. Invest. · 2023
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Sci. Adv. · 2022
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science · 2019
Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling. J. Biol. Chem. · 2016
A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins. Nat. Struct. Mol. Biol. · 2013
Mutations affecting G-protein subunit alpha11 in hypercalcemia and hypocalcemia. N. Engl. J. Med. · 2013
A rude awakening--the perioperative sleep apnea epidemic. N. Engl. J. Med. · 2013
Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Cancer Biol. Ther. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Site-specific analysis of protein S-acylation by resin-assisted capture. J. Lipid Res. · 2011
RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Biol. Reprod. · 2008
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 3 more in the literature graph

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