Neurotensin receptor type 1

Function

G protein-coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, NT1_rcpt, NT_rcpt

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 13

• 2LYW NMR
• 6OS9 EM 3.00A
• 6OSA EM 3.00A
• 6PWC EM 4.90A
• 6UP7 EM 4.20A
• 7UL2 EM 2.40A
• 8JPB EM 3.07A
• 8JPC EM 3.07A
• 8JPF EM 3.02A
• 8ZYT EM 2.65A
• 8ZYU EM 2.65A
• 8ZYY EM 2.83A
• … and 1 more

A predicted model is available from AlphaFold.

Gene Ontology · 45

• GO:0009986 cell surface
• GO:0009898 cytoplasmic side of plasma membrane
• GO:0043198 dendritic shaft
• GO:0043197 dendritic spine
• GO:0005783 endoplasmic reticulum
• GO:0005794 Golgi apparatus
• GO:0045121 membrane raft
• GO:0043204 perikaryon
• GO:0005886 plasma membrane
• GO:0032280 symmetric synapse
• GO:0043195 terminal bouton
• GO:0016492 G protein-coupled neurotensin receptor activity
• GO:0004930 G protein-coupled receptor activity
• GO:0042802 identical protein binding
• GO:0044877 protein-containing complex binding
• GO:0006171 cAMP biosynthetic process
• GO:0007268 chemical synaptic transmission
• GO:1990708 conditioned place preference
• GO:0070779 D-aspartate import across plasma membrane
• GO:0050965 detection of temperature stimulus involved in sensory perception of pain
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0071545 inositol phosphate catabolic process
• GO:0098712 L-glutamate import across plasma membrane
• GO:0043066 negative regulation of apoptotic process
• GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
• GO:0003085 negative regulation of systemic arterial blood pressure
• GO:0007218 neuropeptide signaling pathway
• GO:0043065 positive regulation of apoptotic process
• GO:0090238 positive regulation of arachidonate secretion
• GO:0014054 positive regulation of gamma-aminobutyric acid secretion
• GO:0010628 positive regulation of gene expression
• GO:0014049 positive regulation of glutamate secretion
• GO:0097151 positive regulation of inhibitory postsynaptic potential
• GO:0060732 positive regulation of inositol phosphate biosynthetic process
• GO:0040017 positive regulation of locomotion
• GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
• GO:2000822 regulation of behavioral fear response
• GO:0032960 regulation of inositol trisphosphate biosynthetic process
• GO:0003254 regulation of membrane depolarization
• GO:0043576 regulation of respiratory gaseous exchange
• GO:0032094 response to food
• GO:0033993 response to lipid
• GO:0006950 response to stress
• GO:0001659 temperature homeostasis
• GO:0071625 vocalization behavior

Drugs targeting this protein · 1

• REMINERTANT antagonist

Related proteins · sequence + function similarity

• Neurotensin receptor type 1 0.96
• Neurotensin receptor type 1 0.96
• Neuromedin-U receptor 1 0.91
• Neuromedin-U receptor 1 0.90
• Neuromedin-U receptor 1 0.90
• Neuromedin-U receptor 2 0.88
• Neurotensin receptor type 2 0.88
• Neurotensin receptor type 2 0.88
• Neuromedin-U receptor 2 0.87
• Neurotensin receptor type 2 0.87
• Neuromedin-U receptor 1 0.86
• Neuromedin-U receptor 2 0.86

Co-cited proteins · studied together in the literature

• Neurotensin/neuromedin N 1 shared papers
• Neurotensin receptor type 2 1 shared papers
• Guanine nucleotide-binding protein subunit alpha-11 1 shared papers
• Sortilin 1 shared papers

Literature · 5 cited papers

• Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor. J. Biomol. Struct. Dyn. · 2013
• Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Cancer Biol. Ther. · 2011
• Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. Cancer Res. · 2010
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
• Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. FEBS Lett. · 1993